Key Differences Between Enfamil Neuropro and Similac 360 Total Care
| Aspects | Enfamil NeuroPro | Similac 360 |
|---|---|---|
| Brand Reputation | (Favored by Pediatricians, Adds palm olein, Non-GMO, Gluten-Free, Adds MFGM) | (Breastmilk-like, Five types of HMO, No Palm Olein, Gluten-Free, Non-GMO) |
| Protein Source & Content | Nonfat milk & Whey protein (2g per serve, Whey:Casein = 60:40) | Nonfat milk & Whey protein (2.07g per serve, Whey:Casein = 48:52) |
| Carbohydrate Source & Content | Lactose (11.3g per serve) | Lactose (10.5g per serve) |
| Fat Source & Content | Palm Olein, Coconut, Soy, High Oleic Sunflower Oils, MFGM & DHA Oil (5.3g per serve) | High Oleic Safflower/Sunflower Oil, Soy Oil, Coconut Oil & Algae Oils (5.6g per serve, No Palm Olein) |
| Probiotics & Prebiotics | (GOS Prebiotics) | (5 types of HMO Prebiotics) |
| Availability | (Target), (Walmart) | (Target), (Walmart) |
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This article compares two of the most popular infant formulas in the US: Enfamil Neuropro vs Similac 360.
We will analyze their ingredients and nutritional composition to give you all the information you need to make an informed decision.
Let’s get after it!
*Related: Enfamil Enspire vs Neuropro
Our Short Answer
Another rather complicated comparison.
After analyzing the ingredients and nutritional information of both formulas, we personally would go with Similac 360.
Here are the strengths and weaknesses of both formulas in our view.
Enfamil Neuropro:
+ It has the perfect whey-to-casein ratio for easy digestion (60:40).
+++ Adds MFGM (Milk Fat Globule Membrane), an ingredient found in breast milk, highly beneficial for the baby.
– Uses palm olein, a controversial ingredient, processed from palm oil.Similac 360:
+ Does not use palm oil or derivatives.
+++ Adds five types of HMO (Human Milk Oligosaccharides), the most beneficial prebiotics for babies, found in breast milk.Although Neuropro has its advantages, we believe that looking at the big picture, Similac 360 Total Care is a better choice.
That said, we recommend you look at the alternatives below, as we believe there are even better formulas than Neuropro and 360 Total Care.
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Overview of the Two Formulas
Enfamil Neuropro and Similac 360 Total Care offer cognitive development and immune support.
Neuropro has MFGM and Omega 3 DHA, while Similac has an exclusive 5 HMO prebiotic blend.
Both are non-GMO and gluten-free, suitable for infants aged 0-12 months.
Their nutritional content is similar, with slight differences in protein and carbohydrate amounts.
Enfamil Neuropro
Enfamil Neuropro is a baby formula with a blend of nutrients designed to foster cognitive development and immune support. It’s from the #1 pediatrician-recommended formula brand in the US and it’s suitable for full-term infants aged 0–12 months.
This cow’s milk-based formula has prebiotics and a fat-protein blend of MFGM and Omega 3 DHA previously found only in breast milk.
Moreover, Enfamil Neuropro is gluten-free, non-GMO, and can be bought using HSA/FSA cards (some restrictions apply).
It contains 100 calories per serving (5 fl oz) with principal components being protein (2g), total fat (5.3g), total carbohydrate (11.3g), and water (133g).
Similac 360 Total Care
Similac 360 Total Care is another baby formula making strides due to its uniquely formulated blend for whole-baby support, including immune system, brain development, and digestive health. It contains an exclusive blend of 5 HMO prebiotics identical to those found in breast milk.
The manufacturer claims its composition brings them closer than ever before to breast milk, providing comprehensive care for your baby’s nutrition needs.
Similac 360 Total Care does not contain artificial growth hormones or genetically engineered ingredients – touting itself as non-GMO.
It contains a total of 100 calories per serving (5 fl oz) where major constituents are protein (2.07g), fat (5.6g), carbohydrate (10.5g), and water(134g).
Nutritional Composition
Enfamil Neuropro and Similac 360 Total Care have around 2g of protein per serving.
Both formulas use nonfat milk and whey protein concentrate as their protein sources.
Enfamil has a better whey-to-casein ratio (60:40), mimicking mature breast milk.
Both formulas mainly use lactose as the carbohydrate source and vegetable oils for fats.
Enfamil includes MFGM for added benefits, while Similac avoids palm olein.
Protein Content
Enfamil Neuropro and Similac 360 Total Care deliver approximately 2g of protein per 5 fl oz serving.
In Enfamil Neuropro, the primary source of protein is nonfat milk and whey protein concentrate. Nonfat milk is a complete protein source containing all essential amino acids, while whey protein concentrate is easily digestible and promotes muscle growth.
Similac 360 Total Care also derives its protein primarily from nonfat milk and whey protein concentrate. Like Enfamil, these sources ensure that all essential amino acids are provided to stimulate baby’s growth.
Both formulas use the exact same protein sources: skimmed milk and whey protein, which are what we would expect in conventional formulas.
The main difference is their whey-to-casein ratio, Enfamil Neuropro being 60:40 and Similac 360 being 48:52.
This difference makes Enfamil Neuropro better, since the whey-to-casein ratio in mature breast milk is closer to 60:40, with more whey.
Carbohydrate Content
Enfamil Neuropro provides 11.3g of carbohydrates, predominantly from lactose – this natural milk sugar is identical to the primary carbohydrate found in the mother’s breast milk.
Similac 360 Total Care offers slightly less carbohydrate content per serving (10.5g), also mainly from lactose. The close mimicry of breast milk’s natural carbohydrate source helps promote baby’s digestive health.
No differences regarding carb content, with both formulas using lactose exclusively, which is what we expect from conventional formulas.
No syrups or starches in sight.
Fats and Oils
Enfamil Neuropro uses a blend of vegetable oils (Palm Olein, Coconut, Soy, And High Oleic Sunflower Oils). Additionally, it contains Mortierella Alpina Oil~ (source of ARA) and Schizochytrium Sp. Oil~ (source of DHA), fatty acids important for the brain and eye development. Neuropro also adds MFGM (Milk Fat Globule Membrane), a fatty acid found in breastmilk that is highly beneficial for babies.
Similac 360 Total Care also gets its fats from various oils, including High Oleic Safflower Oil, Soy Oil, Coconut Oil, and Schizochytrium Sp. Oil†(source of DHA)and M. Alpina Oil‡ (source of ARA). A serving contains approximately 5.6g fats.
Regarding fat content, Similac would be the winner because it does not use palm olein like Enfamil; however, the fact that Enfamil adds MFGM makes it a better option, even if it adds palm olein.
*Learn more: Palm oil in Infant Formula
Probiotics and Prebiotics
Enfamil Neuropro has GOS prebiotics, promoting a healthier gut by supporting beneficial bacteria.
Similac 360 Total Care contains five HMO prebiotics, similar to those in breast milk, supporting immune function.
Prebiotics and probiotics in infant formula are not essential ingredients, but they may benefit some babies.
Enfamil Neuropro includes GOS (Galactooligosaccharides) prebiotics in its blend. Prebiotics are dietary fibers that feed the friendly bacteria (probiotics) in your baby’s gut. This boost helps increase the number of beneficial bacteria, contributing to a healthier gut environment.
Similac 360 Total Care stands out here as it includes not one but five different types of HMO (Human Milk Oligosaccharides) prebiotics. These are structurally identical to the ones found in breast milk. HMOs are the third-largest solid component in breast milk and have been found to support immune function.
Best Places to Buy Enfamil Neuropro and Similac 360
Enfamil Neuropro
Similac 360
What are the best alternatives to Enfamil Neuropro and Similac 360?
While both Enfamil Neuropro and Similac 360 offer good nutritional value for your infant, there are other excellent alternatives to consider.
First off is Kendamil Organic. This is our top recommendation because it is made with whole cream milk and real Human Milk Oligosaccharides (HMOs). The formula contains no palm oils, GMOs, or corn syrups. *Read: Enfamil vs Kendamil | Similac vs Kendamil
Next up is Bobbie, an American brand winning our hearts by keeping things simple yet nutritious, with organic ingredients matching EU standards on infant nutrition. *Read: Enfamil vs Bobbie | Bobbie vs Similac 360
The last but not least alternative we recommend is Holle. You can’t go wrong with this brand if you prefer natural and pure ingredients. With Demeter certification reflecting their commitment to biodynamic farming and a clean ingredient list omitting unnecessary components like starches and soy lecithin, Holle resonates with eco-conscious parents wanting nature’s closest nutrition for their babies. *Read: Enfamil vs Holle | Similac vs Holle
Last Words
We hope this comparison between Enfamil Neuropro and Similac 360 helps you make an informed decision.
We strongly advise you to learn more about the alternatives we recommend above before making any purchasing decisions.
If you have any other questions, leave a comment and we’ll get back to you in no time.
See you soon!
We’re Maria and Alberto, a married couple and educators who are nutrition enthusiasts. Even before we had kids, we were already crazy about nutrition.
We’d read scientific articles, watch videos from nutritionists, and spend hours listening to nutrition podcasts.
Today, we continue doing this, but in a different way, as we’ve learned to sift through the noise and trends. Nutrition, like any other field of knowledge, the more you read and learn, the more you develop a comprehensive understanding of reality, and that’s what has happened to us.
Before having our first child, we focused on learning everything we could about child nutrition, using the same techniques we had already employed, backed by our extensive knowledge in nutrition.
Our mission is to help other parents with their children’s nutrition, to help them become the best versions of themselves.
If we are what we eat and drink, which is absolutely true, let’s do it right!
