Key Differences Between Enfamil Neuropro Gentlease and Similac-Pro Advance
| Enfamil Neuropro Gentlease | Similac Pro-Advance | |
|---|---|---|
| Intended for | Babies with digestive issues, lactose intolerance | Babies with no or minor digestive issues |
| Main Protein Source | Partially Hydrolyzed nonfat milk and whey protein | Nonfat milk and whey protein |
| Carbohydrate Source | Corn Syrup Solids | Lactose |
| Fat Source | Includes MFGM, Palm Olein, Soy, Coconut, High Oleic Sunflower Oils | Excludes Palm Olein, includes High Oleic Safflower, Soy, and Coconut Oils |
| Special Ingredients | MFGM for cognitive development | 2′-FL HMO for immune system support |
| Designed For | Eases fussiness, gas, crying within 24 hours, supports cognitive development | Supports immune system, brain & eye development, bone formation |
| Prebiotics/Probiotics | None specified | Contains 2′-FL HMO |
| Recommended Alternatives | Hipp HA, Hipp Comfort and Anti-Reflux | Kendamil Organic, Bobbie |
Blwstore is supported by its audience. When you buy through links on our site, we may earn an affiliate commission.
This article aims to compare two popular infant formulas in the US: Enfamil Neuropro Gentlease vs Similac Pro-Advance.
We will analyze their ingredients and nutritional compositions to help you make an informed decision for your baby.
Let’s get after it!
Related read: Enfamil Gentlease vs Similac Pro-Advance
Our Short Answer
As in our Enfamil Gentlease vs Similac Pro-Advance comparison, it is not easy to pick an absolute winner as both formulas are designed for two different baby profiles.
Choose Enfamil Neuropro Gentlease if:
– Your baby has digestive issues either from cow’s milk protein or lactose.
Choose Similac Pro-Advance if:
– Your baby does not have digestive problems, or if they do, they are entirely within the normal range.
We believe Enfamil Neuropro has the win by adding MFGM (Milk Fat Globule Membrane) to its formula.
As always, we recommend you read about the alternatives further down in the article.
At BLWStore, we may earn a commission from some of the products featured on our website through affiliate partnerships with retailers. We want to be transparent with our readers and let you know that we do not receive any products for special consideration. The commission we earn helps support our website and allows us to continue providing helpful information and product recommendations. Thank you for your support!
Overview of the Two Formulas
Enfamil Neuropro Gentlease is designed to alleviate gas and fussiness, providing complete nutrition for the first 12 months.
Similac Pro-Advance includes 2′-FL HMO for immune support, DHA, lutein, and vitamin E for brain and eye development, and promotes calcium absorption without palm olein oil.
Both formulas are non-GMO.
Enfamil Neuropro Gentlease
Enfamil Neuropro Gentlease is a popular choice among parents seeking to alleviate their baby’s gas and fussiness.
This scientifically designed formula is packed with DHA in quantities as per the World Health Organization’s recommendations.
On top of that, it has been clinically proven to reduce fussiness, gas, crying, and spit-up within 24 hours.
Enfamil NeuroPro Gentlease comes in two main forms: powder and liquid. Each form has versatile size options, providing convenience and flexibility for parents.
What’s great about this formula is that it offers complete nutrition for your baby for the first 12 months, comprising easy-to-digest proteins and essential vitamins and minerals instrumental to immune health.
Similac Pro-Advance
Similac Pro-Advance takes pride in its special formulation incorporating 2’-FL HMO—a prebiotic that closely mimics one found in breast milk—geared towards bolstering your baby’s immune system.
This formula also carries a distinctive blend of DHA, lutein, and vitamin E which are essential for brain and eye development.
The Similac Pro-Advance formula is noted for promoting excellent calcium absorption courtesy of lacking palm olein oil—resulting in stronger bones for your baby.
Alongside immune support features, it also adheres to a non-GMO policy asserting they use no genetically engineered ingredients.
Nutritional Composition
Enfamil NeuroPro Gentlease contains 2.3g of protein from partially hydrolyzed nonfat milk and whey protein concentrate. Similac Pro-Advance has 2.07g of protein from nonfat milk and whey protein concentrate.
Enfamil NeuroPro Gentlease uses corn syrup solids for carbohydrates, while Similac Pro-Advance uses lactose.
Enfamil NeuroPro Gentlease includes MFGM and palm olein, while Similac Pro-Advance avoids palm olein. Both contain DHA and ARA sources.
Protein Content
For every 100 calories (5 fl oz), Enfamil NeuroPro Gentlease supplies 2.3 grams of protein, derived from partially hydrolyzed nonfat milk and whey protein concentrate solids.
On the other hand, Similac Pro-Advance offers slightly lower protein content at 2.07 grams sourced mainly from nonfat milk and whey protein concentrate.
Neuropro Gentlease is specifically formulated for infants dealing with digestive discomforts, so it incorporates partially hydrolyzed milk in its ingredients. It exhibits a whey-to-casein ratio of 60:40, closely akin to the proportions found in natural breast milk.
*Learn more: Extensively hydrolyzed vs partially hydrolyzed formulas
In contrast, Similac Pro-Advance opts for whey protein concentrate, a typical protein source used in standard baby formulas, aimed at infants without gastrointestinal troubles. Pro-Advance showcases a whey-to-casein ratio of 48:52, favoring casein over whey.
Carbohydrate Content
The carbohydrate content differs subtly between the two formulas, with Enfamil Neuropro Gentlease containing slightly more carbohydrates per 100 calories—10.8g versus the 10.5g found in Similac Pro-Advance.
In Enfamil Neuropro Gentlease, the primary carbohydrate source is corn syrup solids, while Similac Pro-Advance utilizes lactose as its major carbohydrate source.
Enfamil Neuropro Gentlease incorporates corn syrup solids as a substitute for lactose, catering to infants with lactose intolerance.
*Learn more: Corn Syrup in baby formula
Similac Pro-Advance strictly utilizes lactose, the main carb found in breast milk, and the carb source we want to find in standard infant formula.
Fats and Oils
Enfamil NeuroPro Gentlease delivers 5.3 grams of fat per 100-calorie serving obtained predominantly from vegetable oils (palm olein, coconut, soy, and high oleic sunflower oils).
Most importantly, Enfamil Neuropro Gentlease includes Milk Fat Globule Membrane (MFGM) — a bioactive compound found in breast milk with shown potential to support cognitive development.
It also adds Mortierella Alpina oil to supply Arachidonic Acid (ARA) and Schizochytrium sp. Oil as a source of Docosahexaenoic Acid (DHA).
Similac Pro-Advance comprises 5.6 grams of fat sourced mainly from high oleic safflower oil, soy oil, coconut oil, and M.Alpina Oil for ARA content and Schizochytrium sp.oil for DHA content.
There are two main differences in the fat content of these two formulas:
Neuropro Gentlease adds palm olein, a more processed version of palm oil. Palm olein is a controversial ingredient that, while it has its benefits, its cons outweigh its pros.
However, it also adds MFGM, a highly beneficial ingredient found in breast milk that supports the immune system, gut health, and cognitive development.
We genuinely think that the addition of MFGM is more important than the fact it also adds palm olein.
Keep learning: DHA and ARA in Baby Formula
Probiotics and Prebiotics
Enfamil NeuroPro Gentlease does not contain probiotics or prebiotics.
Similac Pro-Advance includes 2′-FL HMO, a prebiotic found in breast milk, to support the immune system.
Prebiotics and probiotics in baby formula are not essential, but they may benefit some babies.
Enfamil NeuroPro Gentlease does not incorporate either probiotics or prebiotics in its formula.
Similac Pro-Advance adds 2’-FL HMO, a prebiotic found naturally in breast milk, which has been linked to strengthening the immune system.
Best Places to Buy Enfamil Neuropro Gentlease and Similac Pro-Advance
Enfamil Neuropro Gentlease
Buy Enfamil Gentlease at Target
Buy Enfamil Gentlease at Walmart
Similac Pro-Advance
What are the best alternatives to Neuropro Gentlease and Pro-Advance
Enfamil Neuropro Gentlease Alternatives
Hipp HA: As our top pick for a hypoallergenic formula, Hipp HA features pure and organic ingredients that make it an excellent fit for babies with sensitive digestive systems. *Read: Hipp HA vs Gentlease
Hipp Comfort: A perfect alternative for babies with lactose sensitivities, this specialty formula is designed to be easily digestible.
Hipp Anti-Reflux: If your little one is dealing with acid reflux issues, this specially formulated milk can provide much-needed relief while delivering essential nutrition. *Read: Hipp Comfort vs Anti-Reflux
Similac Pro-Advance Alternatives
Kendamil Organic: We recommend this as an excellent alternative due to its use of whole milk and the inclusion of real HMOs that enhance immune support. It’s also packed with nutritious full-cream nutrients making it an exceptional choice for healthy growth. *Read: Kendamil vs Enfamil | Kendamil vs Similac
Bobbie: For parents seeking US-made options, Bobbie offers an impressive combination of simplicity and organic ingredients ideal for your baby’s overall health. *Read: Bobbie vs Gentlease | Bobbie vs Pro Advance
Last Words
We sincerely hope this comparison between Enfamil Neuropro Gentlease and Similac Pro Advance helps you make an informed decision.
We recommend you learn more about the alternatives above until you find a formula that you are comfortable with.
If you need further help, please comment below, and we’ll get back to you in less than a day.
See you around!
We’re Maria and Alberto, a married couple and educators who are nutrition enthusiasts. Even before we had kids, we were already crazy about nutrition.
We’d read scientific articles, watch videos from nutritionists, and spend hours listening to nutrition podcasts.
Today, we continue doing this, but in a different way, as we’ve learned to sift through the noise and trends. Nutrition, like any other field of knowledge, the more you read and learn, the more you develop a comprehensive understanding of reality, and that’s what has happened to us.
Before having our first child, we focused on learning everything we could about child nutrition, using the same techniques we had already employed, backed by our extensive knowledge in nutrition.
Our mission is to help other parents with their children’s nutrition, to help them become the best versions of themselves.
If we are what we eat and drink, which is absolutely true, let’s do it right!
