Similac-360-Total-Care-Sensitive-vs-Enfamil-Neuropro-Gentlease

Key Differences Between Similac 360 Total Care Sensitive and Enfamil Neuropro Gentlease

Key DifferencesSimilac 360 Total Care SensitiveEnfamil Neuropro Gentlease
Origin USA USA
Brand ReputationTrusted, history of innovationPioneering formula advancements
Protein Content2.1g per serving2.3g per serving
Unique Protein FeatureMilk protein isolate – similar to whole cow’s milkPartially hydrolyzed nonfat milk and whey protein concentrate
Carbohydrate ContentCorn Syrup and Sugar, 10.9g per servingCorn Syrup Solids, 10.8g per serving
Carbohydrate BenefitsNo lactose, for lactose sensitive babiesNo specified sugar/lactose content, same
Fats and OilsHigh Oleic Safflower Oil, Soy Oil, and Coconut OilVegetable Oil blend with Palm Olein
Omega Fatty AcidsDHA and ARADHA and ARA
Prebiotics and ProbioticsBlend of 5 HMO prebioticsNo specified inclusion
Formulated forBabies without cow’s milk protein allergy but lactose sensitivitieBabies with trouble digesting cow’s milk protein
Special NoteNo palm olein, contains probioticsPediatrician recommended for babies with cow’s milk protein allergy
Best places to buyTarget, WalmartTarget, Walmart

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Are you looking for a gentle formula for your baby’s tummy?

We have reviewed and compared hundreds of different formulas, and it’s time for Similac Sensitive and Enfamil Gentlease.

Both promise to cater to your baby’s sensitive tummy while supporting healthy growth, but which one truly delivers?

In this article, we will delve into every important detail, from their brand reputations and nutritional composition to pre and probiotics and alternatives.

We aim to give you the information you need to make an informed decision.

Let’s get after it!

*We will compare their most up-to-date versions: Similac 360 Total Care Sensitive vs Enfamil Neuropro Gentlease

*Related reads: Enfamil Gentlease vs Similac Alimentum | Similac Sensitive vs 360 Sensitive | Similac 360 Total Care vs Enfamil Neuropro

Our Short Answer

After analyzing both formulas’ ingredients and nutritional information, we have our personal winner, although your decision will depend on your baby’s situation.


Choose Similac 360 Total Care Sensitive if:

– Your baby doesn’t have a cow’s milk protein allergy.

– You want a formula without palm olein.

– You want a formula with probiotics.


Choose Enfamil Neuropro Gentlease if:

– Your baby has trouble digesting cow’s milk protein or an allergy.

– Your pediatrician has recommended a hydrolyzed formula.


Both formulas will work well if your baby has trouble digesting lactose, so if that is your specific case, we recommend you choose Similac Sensitive as it has no palm olein and has HMOs, the best probiotics for babies.

We recommend reading our article on the best hypoallergenic formulas if you are interested in these two formulas.

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Brand Reputation

Similac: Highly regarded brand trusted by parents and healthcare professionals. Known for innovation and research, but had a recall in 2010 (handled transparently).

Enfamil: Venerated brand with formula advancements. Experienced a recall in 2011, but investigation showed no connection between infections and their powder formula.

Similac Reputation

Similac is a highly regarded brand within the realm of infant nutrition.

Produced by Abbott Laboratories, a global healthcare company with over 130 years in business, Similac products have been trusted by parents and recommended by healthcare professionals for decades.

Their commitment to innovation and scientific research is evident with significant milestones like being the first leading infant formula brand free from artificial growth hormones.

However, it hasn’t been all smooth sailing for Similac.

In 2010, Similac had a voluntary recall due to beetle contamination found in their powdered formulas.

Nevertheless, the company handled this issue transparently and swiftly — leading some parents to view this as a testament to their commitment towards safety.

Enfamil Reputation

Enfamil is another venerated name in baby nutrition developed by Mead Johnson & Company, which has been in business since 1905.

Enfamil products are renowned for pioneering formula advancements that closely mimic breast milk’s benefits as well as supporting brain development – again, backed by scientific studies.

But like Similac, Enfamil has also dealt with recalls.

Back in 2011, Enfamil Newborn powder was linked to two cases of bacterial infections.

However on further investigations conducted by Federal health officials concluded that no connection existed between the instances of infection and Enfamil powder formula.

Nutritional Composition

Examining their nutritional composition is one of the most critical factors when comparing baby formulas.

Let’s look closer at their protein, carbohydrate, and fat content.

Similac Sensitive: Milk Protein Isolate, corn syrup solids (no lactose), no palm olein.

Enfamil Gentlease: Partially hydrolyzed milk, corn syrup solids (no lactose), vegetable oil with palm olein.

Similac has free protein, while Gentlease partially breaks down proteins for easier digestion.

Enfamil uses palm olein in fats, while Similac does not.

Protein Content

Similac Sensitive uses Milk Protein Isolate as its primary source of protein. This complete protein contains all essential amino acids required for the growth and development of your infant. Each serving (100 Calories or 5 fl oz) provides 2.1 grams of protein.

Enfamil Gentlease, on the other hand, uses a blend of partially hydrolyzed nonfat milk and whey protein concentrate solids (from soy), making it easier to digest for sensitive tummies. A serving size offers slightly more protein than its Similac counterpart with 2.3 grams per serving.

Both formulas use a very different protein source.

Similac uses milk protein isolate, basically free protein without other non-protein components. It is used in standard infant formulas and is closer to whole cow’s milk composition.

Gentlease uses partially hydrolyzed milk, meaning the proteins have been partially broken down, making them easier to digest for babies who have trouble digesting cow’s milk protein.

Carbohydrate Content

Similac Sensitive’s main carbohydrate source is Corn Syrup, followed by Sugar, delivering 10.9 grams per serving size. It must be noted that this particular variant is designed for lactose-sensitive infants; hence, lactose isn’t included.

Enfamil Gentlease also uses Corn Syrup Solids as its leading source of carbohydrates but doesn’t specify singular sugar or lactose content— providing nearly identical carbohydrate amounts with 10.8 grams per serving.

Both formulas are fairly similar, but the fact that Similac adds ordinary sugar and Gentlease does not gives Enfamil a head start in carb content.

Fats and Oils

The fat sources in Similac Sensitive mainly include High Oleic Safflower Oil, Soy Oil, and Coconut Oil, supplying 5.4 grams per serving size.

Enfamil Gentlease derives its fats from Vegetable Oil (consisting of Palm Olein, Coconut, Soy, and High Oleic Sunflower Oils).

Both formulas include DHA and ARA.

In terms of fat content, Similac comes out ahead simply because it does not use Palm Olein, which is a more processed version of palm oil.

Although palm oil has a compound called palmitic acid, a fatty acid very similar to those in breast milk, the cons outweigh the pros of palm olein, which makes Similac Sensitive win the fat battle.

The only instance where palm oil is not a problem is when it is organically grown.

Probiotics and Prebiotics

Similac Sensitive: Contains exclusive blend of 5 HMO prebiotics, not sourced from human milk.

Enfamil Gentlease: No specified inclusion of prebiotics or probiotics.

Similac Sensitive stands out with its exclusive blend of 5 HMO (Human Milk Oligosaccharides) prebiotics structured identically to breast milk. However, it’s worth noting that these HMOs are not sourced from human milk.

In contrast, Enfamil Gentlease does not specify the inclusion of prebiotics or probiotics in their formula.

Best Places to Buy Similac Sensitive and Enfamil Gentlease

Target-Logo
Walmart-Logo

Similac 360 Total Care Sensitive

Buy Similac Sensitive at Target

Buy Similac Sensitive at Walmart

Enfamil Neuropro Gentlease 

Buy Enfamil Gentlease at Target

Buy Enfamil Gentlease at Walmart

What are the best alternatives to Similac Sensitive and Enfamil Gentlease?

While Similac Sensitive and Enfamil Gentlease both have their distinct benefits, it’s beneficial exploring other alternatives that may better suit your baby’s unique needs:

  1. Hipp HA Combiotic: This German-based formula employs hydrolyzed proteins making it easier to digest while including probiotics and prebiotics for gut health. *Read: Hipp HA vs Gentlease

  2. Hipp Comfort: Designed specifically for infants with digestion troubles like gas or constipation, Hipp Comfort is lactose-reduced and uses easily digestible milk protein fractions. *Read: Hipp Comfort vs HA

  3. Bobbie Organic Gentle Infant Formula: This US-based option offers organic, non-GMO ingredients alongside a balanced blend of carbohydrates and proteins tailored for sensitive tummies. *Read: Best Hypoallergenic formulas

  4. Kendamil Goat or Nannycare: If you’re considering goat milk formulas, both Kendamil Goat and Nannycare offer high-quality options. They feature all necessary nutrients for development while being naturally gentle on the baby’s tummy as goat’s milk protein forms a softer curd than cow’s milk protein which can be more comfortable to digest. *Read: Kendamil goat vs Nannycare

Last Words

Thank you for reading the whole article.

We sincerely hope this post comparing Similac Sensitive vs Enfamil Gentlease has helped you make an informed decision.

See you around!

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