Similac-Pure-Bliss-vs-360-Total-Care

Key Differences Between Similac Pure Bliss and 360 Total Care

Key DifferencesSimilac Pure BlissSimilac 360 Total Care
Source of MilkMilk from free-range Irish cowsStandard milk source
PrebioticsGalactooligosaccharides (GOS) for digestive health5 HMO prebiotics for immune system and brain development
GMONon-GMONon-GMO
Grass-fedYesNo
Protein SourceNonfat milk and whey protein concentrateNonfat milk and whey protein concentrate
Carbohydrate SourceLactoseLactose
Fats and Oils SourceHigh oleic sunflower oil, soy oil, coconut oilHigh oleic sunflower oil, soy oil, coconut oil
Palm OilNo palm oil or palm oleinNo palm oil or palm olein
OverallOur first choice for using milk from free range cowsA close second for adding 5 HMO prebiotics

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This article compares two popular Similac formulas: Pure Bliss vs 360 Total Care.

We will analyze their ingredients and nutritional composition to give you the information you need to make an informed decision.

Let’s get after it!

Related read: Similac Pure Bliss vs Sensitive

Our Short Answer

If this is not one of the most tied comparisons on our website, it is very close to being one.

Both formulas are virtually the same, except for these two factors:

– Similac Pure Bliss uses milk from free-range Irish cows.

– Similac 360 Total Care uses HMOs: the best prebiotic for babies.

Besides these two differences, both formulas are the same, and you will realize that as you read the article.

That said, you must see which factor is more important to you.

In our personal opinion, we believe that the origin of the ingredients is one of the most critical factors in nutrition, and more so in infant nutrition.

Therefore, Pure Bliss would be our first choice if we had to choose.

Before you make a decision, we recommend you read about the alternatives below in the article.

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Overview of the Two Formulas

Similac Pure Bliss mirrors breast milk, gentle on digestion, antibiotic and palm olein oil-free, features grass-fed cow milk, and includes DHA and ARA.

Similac 360 Total Care mimics breast milk with five HMO prebiotics, aids immunity, brain and digestion. No artificial hormones, suitable for SNAP benefits.

Similac Pure Bliss

Pure Bliss by Similac is specially crafted to mimic the nutritional composition of breast milk. It claims to be easy on digestion and gentle for little tummies, a critical factor for newborns’ sensitive systems.

Pure Bliss doesn’t contain antibiotics or palm olein oil and is non-GMO.

One of its standout features is the use of milk from grass-fed cows, bringing added reassurance to parents seeking more natural options.

This formula also contains DHA and ARA to support your baby’s brain and eye development. Its focus areas include growth support, eye, and brain development, immune system support, and issues like fussiness, gas, and digestion.

Similac 360 Total Care

Similac 360 Total Care is another powerhouse infant formula that has tackled the challenge of reflecting the benefits of breast milk meticulously.

It’s made using an exclusive blend of five HMO prebiotics structurally identical to those found in breast milk.

This resemblance helps to enhance immune support, brain development, and digestive health.

Like Pure Bliss, 360 Total Care also boasts the leading edge of being a brand that doesn’t use artificial growth hormones.

Plus, it contains non-genetically engineered ingredients.

If you’re using SNAP benefits, this formula can be purchased with them at selected stores.

Nutritional Composition

Both Pure Bliss and 360 Total Care have 2.07g protein per serving, sourced from nonfat milk and whey protein concentrate with a 48:52 whey-to-casein ratio.

They offer similar carbohydrate content, around 10.7g and 10.5g, from lactose without additives.

Both contain 5.6g fat from sunflower, soy, coconut oils, DHA, and ARA.

Pure Bliss excels in milk quality.

Protein Content

The protein content in both Pure Bliss and 360 Total Care is 2.07g per prepared serving of 5.3 fl oz.

They get their protein primarily from nonfat milk and whey protein concentrate.

Both formulas use skimmed milk and whey protein concentrate, the standard protein sources for ordinary formulas. They have the same whey-to-casein ratio of 48:52.

The only difference is the milk quality: Pure Bliss uses milk from grass-fed cows, which we can expect to have a better quality than the standard milk used in other formulas.

Carbohydrate Content

Carbohydrates provide the energy that fuels your little one’s daily activities and growth.

Pure Bliss and 360 Total Care have similar carbohydrate amounts at approximately 10.7g and 10.5g per serving, respectively.

Their primary carbohydrate source is lactose with no starch, maltodextrin or corn syrup solids.

Both formulas use only lactose, which is what we expect from non-specialty formulas.

The only difference is the quality of the milk from which they extract the lactose, Pure Bliss being the winner again.

Fats and Oils

Fats are crucial to your baby’s diet as they supply essential fatty acids and serve as an energy store.

Pure Bliss and 360 Total Care contain 5.6g of fat per serving, as directed.

In both formulas, the fat comes from high oleic sunflower oil, soy oil, coconut oil, Schizochytrium sp. oil, a source of DHA (docosahexaenoic acid), and M. Alpina Oil, a source of ARA. 

Both formulas have the exact same fat profile with no differences whatsoever.

A non-organic vegetable oil blend without palm olein (perfect) and DHA and ARA on top of that. The only thing that would have made this blend better is being organic.

Probiotics and Prebiotics

Similac Pure Bliss uses Galactooligosaccharides (GOS) for prebiotic support, while 360 Total Care includes Human Milk Oligosaccharides (HMOs) as superior prebiotics.

Neither formula contains probiotics, but 360 Total Care excels with HMOs, mirroring breast milk’s benefits for gut health.

Probiotics and prebiotics can significantly influence your baby’s gut health in their diet—both help promote a healthy digestive system.

Similac Pure Bliss incorporates Galactooligosaccharides (GOS), a prebiotic that aids in encouraging the growth of beneficial gut bacteria, thus supporting overall gut health and digestion. However, it does not contain any probiotics.

Similac 360 Total Care, on the other hand, includes five distinctive Human Milk Oligosaccharides — 2′-Fucosyllactose, Lacto-N-Tetraose, 3-Fucosyllactose, 6′-Sialyllactose, and 3′-Sialyllactose. These are beneficial compounds structurally identical to those found in breast milk that serve as food (prebiotics) for gut bacteria. But like Pure Bliss, 360 Total Care also contains no probiotics.

Similac 360 Total Care wins in this aspect since HMOs are the best prebiotic for babies.

Best Places to Buy Similac Pure Bliss and 360 Total Care

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Buy Similac Formula at Target 

Buy Similac Formula at Warlmart

What are the best alternatives to Similac Pure Bliss and 360 Total Care?

Even though Similac Pure Bliss and 360 Total Care are high-quality formulas, we prefer other brands out there.

These are our top 4 recommendations:

  • Kendamil Organic: This is our top pick for the best alternative baby formula. It stands out for being organic, containing real Human Milk Oligosaccharides sourced from actual breast milk (and not made chemically), and utilizing whole milk as a base. *Read: Kendamil vs Pure Bliss

  • Bobbie: If you’re looking for a formula with a short and simple list of ingredients, Bobbie is our top US-based pick. Clean and straightforward, this formula avoids unnecessary frills, focusing on providing purely what your baby needs. *Read: Bobbie vs Pure Bliss

  • Holle: Holle is a strong contender for parents who prioritize purity and organic ingredients. With its Demeter certification, this formula assures high-quality standards, making it one of the purest, most organic formulas around. *Read: Holle vs Similac

  • Hipp: The best brand for specialty formulas, Hipp offers a powerful blend of prebiotics and probiotics. It also has formulas with reduced lactose content, catering to babies with specific dietary needs. *Read: Hipp vs Similac

Last Words

We sincerely hope this comparison between Similac Pure Bliss and 360 Total Caree has helped you choose the best option.

We encourage you to learn more about the alternatives above before you make a purchasing decision.

If you have further questions, leave a comment, and we’ll get back to you in less than a day.

Happy feeding!

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