Key Differences Between Enfamil Reguline and Similac Total Comfort
| Aspects | Enfamil Reguline | Similac Total Comfort |
|---|---|---|
| Brand Reputation | (Trusted by Many, Addresses Constipation, Non-GMO, Gluten-Free) | (Easy Digestion, Lactose-Free, Gluten-Free, No Palm Olein) |
| Protein Source & Content | Nonfat milk & Whey protein (Partially Hydrolyzed, Whey:Casein = 60:40) | Partially Hydrolyzed Whey protein (Soy-Free, Whey:Casein = 48:52) |
| Carbohydrate Source & Content | Corn Syrup Solids & Lactose | Corn Maltodextrin (Added Sugar, Lactose-Free) |
| Fat Source & Content | Palm Olein, Coconut, Soy, High Oleic Sunflower Oils (Includes DHA Oil) | High Oleic Safflower Oil, Soy Oil, Coconut Oil (No Palm Olein) |
| Probiotics & Prebiotics | (Dual Prebiotic Blend with Galactooligosaccharides, No Probiotics) | (Short-Chain Fructooligosaccharides, No Probiotics) |
| Availability | (Target), (Walmart) | (Target), (Walmart) |
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This post compares two popular sensitive infant formulas in the US: Enfamil Reguline vs Similac Total Comfort.
We will analyze their ingredients and nutritional compositions to help you make an informed decision.
Let’s get after it!
*Related read: Enfamil Reguline vs Enfamil Neuropro Gentlease
Our Short Answer
Another extremely close comparison. After analyzing the ingredients and nutritional information of both formulas, this is our verdict:
Enfamil Reguline is a better choice, in our opinion, for the simple fact that Similac Total Comfort adds simple sugars. This even considers that Reguline uses palm olein in its formula.
The only case in which you should choose Total Comfort is if your baby has strong lactose intolerance, as Enfamil Reguline does not entirely eliminate lactose.
Having said all this, we recommend you read about the alternatives we recommend below in the article.
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What About Reguline vs Similac Pro-Total Comfort?
The only difference between Total Comfort and Pro-Total Comfort is that the “Pro” version adds a special prebiotic called 2′-FL HMO, highly beneficial for babies.
*Learn more: Similac Total Comfort vs Pro-Total Comfort
Still, we stand by our verdict, Reguline would come out on top in our eyes unless your baby suffers from lactose intolerance.
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Overview of the two formulas
Enfamil Reguline aids with occasional constipation while providing balanced nutrition, promoting softer stools with easy-to-digest proteins and prebiotics.
It supports brain and immune system development with omega-3 DHA, Choline, and essential vitamins.
Similac Total Comfort offers easily digestible nutrients, ideal for sensitive tummies and lactose sensitivity.
It includes DHA, Lutein, and other vital vitamins for overall growth. Both formulas are gluten-free.
Enfamil Reguline
Enfamil is trusted by many folks out there regarding baby nutrition.
The primary mission of Enfamil Reguline is to help your little one deal smoothly with occasional constipation scenarios without sacrificing any part of balanced nutrition throughout their first 12 months.
Reguline incorporates a unique blend of easy-to-digest proteins and dual prebiotics scientifically proven to promote softer and more comfortable stools within the first week of use.
Moreover, aside from assisting on rough pooping days, it also supports brain & immune system development – thanks to its omega 3 DHA, Choline content, and other essential vitamins.
Reguline is ready–to–mix in powdered form–useful whether at home or on the go!
Similac Total Comfort
Another big player on the block is Similac with its popular product called ‘Total Comfort’.
What makes it stand out?
Similac’s specialized infant formula boasts an easily digestible blend of full-fat nutrients like high oleic safflower oil along with partially hydrolyzed protein which minimizes potential tummy problems tied often link to milk-based formula consumption.
Furthermore—similarly like our precious contestant—it doesn’t skip other necessary microelements supporting infants’ overall growth such as DHA (a type of Omega 3 fatty acid), Lutein important for eyesight development, or another long list including health-supporting substances such as Vitamin A Palmitate or Niacinamide.
It was designed just fine even if your little treasure struggles with lactose sensitivity. Also—it’s gluten-free.
Nutritional Composition
Enfamil Reguline and Similac Total Comfort both have partially hydrolyzed proteins for easier digestion.
Enfamil uses soy and has a better whey-to-casein ratio, while Similac avoids soy.
Reguline uses corn syrup solids and lactose, while Total Comfort uses corn maltodextrin with added sugar.
Reguline uses Palm Olein, while Similac uses High Oleic Safflower Oil, making it a better choice for those concerned about palm oil use.
Protein Content
Enfamil Reguline: The protein source for Enfamil Reguline comes from nonfat milk and whey protein concentrate solids (soy). Having a partially hydrolyzed form—broken down into smaller pieces—it can be easier for an infant’s immature digestive system to process.
Similac Total Comfort: Similar to Enfamil, Similac Total Comfort also uses a partially hydrolyzed form of whey protein as its source, which makes it easy on your little one’s tummy.
While both brands use partially hydrolyzed proteins to ease digestion, the primary difference lies in their sources—Enfamil taps into soy while Similac avoids it completely. (This only matters if your baby is allergic to soy)
*Learn more: Soy in Baby Formula | Hydrolyzed Formulas
Enfamil’s whey-to-casein ratio is 60:40, the closest to mature breastmilk. However, Similac’s has 48:52, a bit less ideal.
Carbohydrate Content
Enfamil Reguline: The chief carbohydrate source here is Corn Syrup Solids with some Lactose included
Similac Total Comfort: This brand opts for Corn Maltodextrin as its principal carbohydrate component, along with added sugar.
Both brands maintain a similar approach by primarily utilizing corn derivatives, but maltodextrin is a less sugary option than syrup solids. However, Total Comfort also adds extra sugar on top of the maltodextrin, something we do not like.
If your baby suffers from lactose intolerance or sensitivity, Total Comfort is your best bet, because it avoids lactose altogether.
For any other case, Reguline is a better choice.
Fats and Oils
Enfamil Reguline: It uses Palm Olein oil combined with other oils like Coconut oil, Soy oil,
and High Oleic Sunflower oils.
Similac Total Comfort: Takes an allergen-free approach by using only High Oleic Safflower Oil mixed with Soy Oil & Coconut Oil.
While both ensure sufficient fat content required considering overall childhood nutrition needs – if you’re more “palm-conscious” due to slight absorption differences or environmental considerations – Similac stands out as the clear winner here.
*Learn more: Palm Oil in Baby Formula
Probiotics and Prebiotics
Reguline uses galactooligosaccharides, while Total Comfort uses short-chain fructooligosaccharides.
Both are beneficial, but neither formula includes probiotics.
Probiotics and prebiotics are essential in maintaining gut health, a key element in supporting immunity, but they are not mandatory ingredients in baby formulas.
Enfamil Reguline and Similac Total Comfort include these helpful little buddies, albeit under different names.
Enfamil Reguline uses a dual probiotic blend with galactooligosaccharides (a prebiotic) to enhance soft stool production.
Similac Total Comfort sticks with its short-chain fructooligosaccharides (another prebiotic).
GOS and scFOS have been shown to affect infant health positively, so there is no clear winner in this aspect.
No probiotics are found in either formula.
Best Places to Buy Enfamil Reguline and Similac Total Comfort
Enfamil Reguline
Similac Total Comfort
Buy Similac Total Comfort at Target
Buy Similac Total Comfort at Walmart
What are the best alternatives to Enfamil Reguline and Similac Total Comfort?
Consider Hipp Comfort or Anti-Reflux if you’re on a quest for something digestibility-focused & great for lactose sensitivities. Known for their commitment to organic ingredients, Hipp offers specialized solutions. Perfect whether your baby struggle with common digestive issues or more specific ones linked to lactose sensitivity.
When it comes to hypoallergenic formulas—the best bet is often Hipp HA. Babies experiencing food allergies can take solace in knowing this product was formulated with their specific needs – reducing potential allergens without compromising nutrition! *Read: Hipp HA vs Enfamil Gentlease
Lastly, you might want to consider exploring goat milk-based options (only if your baby is not diagnosed with CMPA):
Kendamil Goat offers a high-quality formula choice while companies such as Nannycare also cater specifically towards goat milk nutrition realm providing equally viable alternative traditional cow’s-milk-based products got used to. *Read: Kendamil Goat vs Nannycare
Last Words
We hope this comparison between Enfamil Reguline and Similac Total Comfort helps you make an informed decision.
We strongly encourage you to learn about the alternatives before making any purchasing decisions.
If you have further questions leave a comment and we’ll get back to you in no time!
Happy Feeding!
We’re Maria and Alberto, a married couple and educators who are nutrition enthusiasts. Even before we had kids, we were already crazy about nutrition.
We’d read scientific articles, watch videos from nutritionists, and spend hours listening to nutrition podcasts.
Today, we continue doing this, but in a different way, as we’ve learned to sift through the noise and trends. Nutrition, like any other field of knowledge, the more you read and learn, the more you develop a comprehensive understanding of reality, and that’s what has happened to us.
Before having our first child, we focused on learning everything we could about child nutrition, using the same techniques we had already employed, backed by our extensive knowledge in nutrition.
Our mission is to help other parents with their children’s nutrition, to help them become the best versions of themselves.
If we are what we eat and drink, which is absolutely true, let’s do it right!
