Key Differences Between Enfamil Reguline and Similac 360 Total Care Sensitive
| Feature | Enfamil Reguline | Similac 360 Total Care Sensitive |
|---|---|---|
| Targeted for | Babies with occasional constipation | Babies with lactose sensitivity |
| Protein source | Partially hydrolyzed nonfat milk and whey protein concentrate solids (soy) | Milk protein isolate |
| Carbohydrate source | Corn syrup solids and lactose | Corn syrup and sugar |
| Fat source | Blend of vegetable oils including palm olein oil | High Oleic Safflower Oil, Soy Oil, and Coconut Oil (No palm oil) |
| Prebiotics | Polydextrose and galactooligosaccharides | 5 Human Milk Oligosaccharides (HMO prebiotics) |
| Main Benefit | Promotes soft, comfortable stools | Closest formula to breast milk for sensitive tummies |
| Purchase using SNAP benefits | Yes | Yes |
| ⭐ Overall Recommendation | For babies who have trouble digesting cow’s milk protein, but do not have lactose intolerance issues | For babies who have no problems digesting cow’s milk protein and have lactose sensitivity issues |
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This article aims to compare two sensitive formulas in the US: Enfamil Reguline vs Similac 360 Total Care Sensitive.
We will analyze their ingredients and nutritional information to help you make an informed decision.
Let’s get started!
*Related read: Enfamil Reguline vs AR (Anti-Reflux)
Our Short Answer
After analyzing the ingredients and nutritional composition of both formulas, Similac 360 is a more complete formula and the one we would choose for our baby, but this will not be true for all parents.
Choose Enfamil Reguline if:
– Your baby has trouble digesting cow’s milk protein, but does not have lactose intolerance issues.
Choose Similac 360 Total Care Sensitive if:
– Your baby has no problems digesting cow’s milk protein.
– Your baby has problems with lactoseWe say Similac 360 is our choice between the two because it has no palm olein and its prebiotic blend is more beneficial than Reguline’s, as it uses HMOs, prebiotics found in breast milk, which are very beneficial for babies.
That said, the first thing to do is to consider your baby’s needs and choose the best formula based on that. If you don’t know what digestive problem your baby has, consult your pediatrician.
We recommend exploring the alternatives below in the article before buying one of these two formulas.
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Overview of the two formulas
Enfamil Reguline promotes soft stools, providing complete nutrition with prebiotics, vitamins, omega-3 DHA, Choline, and dual probiotics for bowel regulation. Main ingredients are partially hydrolyzed nonfat milk and whey protein concentrate.
Similac 360 Total Care Sensitive eases tummy troubles with HMO prebiotics, supporting immune, brain, and digestive health. It uses milk protein isolate and is non-GMO with no artificial growth hormones.
Both formulas can be purchased using Supplemental Nutrition Assistance Program (SNAP) benefits.
Enfamil Reguline
Enfamil Reguline is a reputable baby formula designed to promote soft and comfortable stools within the first week of use.
This formula delivers complete nutrition for your child’s first 12 months, with prebiotics, vitamins, omega-3 DHA, Choline, and 30 other nutrients that complement your baby’s diet, supporting brain development and immune support.
Enfamil Reguline also comes with a dual probiotic blend which works great at helping regulate your little one’s bowel movements.
The main ingredient in this formula is partially hydrolyzed nonfat milk and whey protein concentrate solids, which are easy to digest.
The product is tailored for infants facing occasional constipation – it helps make stool softer and more comfortable to pass.
Similac 360 Total Care Sensitive
Similac® 360 Total Care® Sensitive Infant Formula is designed to ease common tummy troubles like fussiness and gas brought on by lactose sensitivity.
It contains an exclusive blend of five Human Milk Oligosaccharides (HMO prebiotics) identical to those found naturally in breast milk.
This formula offers 360-degree support through its nutrient content designed for immune support, brain development, digestive health – everything your little one needs from birth onwards.
SIMILAC 360 prides itself on being close to breast milk in terms of sensitive formula while being non-GMO (not genetically engineered) with no artificial growth hormones.
The main protein source here is derived from milk protein isolate.
Nutritional Composition
Enfamil Reguline has partially hydrolyzed nonfat milk and whey protein concentrate (soy).
SIMILAC 360 Total Care Sensitive has milk protein isolate.
Reguline has 11.1g carbohydrates from corn syrup and lactose, while Similac has 10.9g from corn syrup and sugar (for lactose sensitivity).
Fat sources differ; Reguline includes palm oil, while Similac has a better fat profile with no palm oil.
Protein Content
Proteins are the building blocks of your baby’s body. They contribute to the growth and repair of tissues, organs, antibodies, enzymes, and hormones.
Enfamil Reguline’s protein content per 5oz serving is 2.3g. The source of this protein comes from partially hydrolyzed nonfat milk and whey protein concentrate solids (soy), which are easily digestible by babies.
On other hand, SIMILAC 360 Total Care Sensitive offers a slightly lower protein content of 2.1g per 5oz serving. The protein source here is milk protein isolate.
There is a vital difference between both formulas.
Reguline uses partially hydrolyzed protein. This means it is pre-digested, making it easier for babies to process.
Learn more: Hydrolyzed Infant Formulas
Similac 360 uses milk protein isolate, meaning it has been isolated from any other chemicals, including lactose, to make it easier to digest for babies with lactose intolerance. However, the protein is not modified, so it is unsuitable for babies with problems digesting cow’s milk protein.
Carbohydrate Content
Carbohydrates are integral for providing energy to support your baby’s rapid growth and high energy levels.
Enfamil Reguline provides 11.1g of carbohydrates per serving, mainly from corn syrup solids and lactose (milk sugar).
Contrarily, SIMILAC 360 Total Care Sensitive has 10.9g carbohydrates per serving sourced from corn syrup and sugar.
Similac 360 should be your first choice if your baby has lactose sensitivity since it avoids lactose altogether. We do not like the fact that it adds sugar on top of the corn syrup solids (which are already quite sweet)
Enfamil Reguline uses corn syrup solids and adds a bit of lactose. This option is better, but only for babies without severe lactose sensitivities.
Fats and Oils
Fats give your baby essential fatty acids that their body cannot produce alone. They also supply fat-soluble vitamins A, D, E, K plus Omega-3 DHA, necessary for brain development.
In Enfamil Reguline, fats come from a blend of vegetable oils, including palm olein oil, coconut oil, soy oil, high oleic sunflower oil, Mortierella Alpina Oil (source of arachidonic acid (ARA)), Crypthecodinium Cohnii Oil(Docosahexaenoic acid (DHA)), providing a total fat content of 5.3g per serving.
SIMILAC 360 Total Care Sensitive derives its fat contents from High Oleic Safflower Oil, Soy Oil, and Coconut Oil, with total fats slightly higher at 5.4g per serving. It also adds C. Cohnii Oil (DHA) and M. Alpina Oil (ARA), like reguline.
The main and critical difference in fat content is that Enfamil Reguline uses palm oil, a more processed version of palm oil.
Even though palm oil has its benefits, studies have linked it with poor calcium absorption, which is why we prefer to avoid it, unless it comes from organic sources and it is actually palm oil.
*Learn more: Palm Oil in Baby Formula
This is why, Similac 360 has a better fat profile than Reguline.
Probiotics and Prebiotics
Enfamil Reguline contains polydextrose and galactooligosaccharides as dual prebiotics, promoting soft stools.
SIMILAC 360 Total Care Sensitive includes 5 Human Milk Oligosaccharides (HMO prebiotics), supporting gut health similarly to breast milk.
Prebiotics and probiotics play a fundamental role in a baby’s digestive health. Prebiotics act as food for beneficial gut bacteria, while probiotics are live healthy bacteria.
Enfamil Reguline has dual prebiotics designed to promote soft stools within the first week of use: polydextrose and galactooligosaccharides, which act as prebiotic fibers enriching the healthy gut bacteria.
SIMILAC 360 Total Care Sensitive gears towards improving gut health with its blend of 5 structurally identical Human Milk Oligosaccharides (HMO prebiotics) to those in breast milk.
Best Places to Buy Enfamil Reguline and Similac 360 Sensitive
Enfamil Reguline
Similac 360 Total Care Sensitive
Buy Similac Sensitive at Target
Buy Similac Sensitive at Warlmart
What are the best alternatives to Enfamil Reguline and Similac 360?
Hipp HA: This is our favorite hypoallergenic formula due to its organic ingredients. Its highly beneficial pre and probiotic blend, along with its protein significantly broken down into smaller particles making it easier to digest, makes it a standout candidate. *Read: Hipp HA vs Enfamil Gentlease
Hipp AR and Hipp Comfort: These two options can be real game-changers for lactose-sensitive babies. They provide customized nutrition for infants needing dietary management of reflux, regurgitation, or colic, respectively. *Read: Hipp Comfort vs Anti-Reflux
Goat milk formulas like Kendamil Goat and Nannycare: Consider these high-quality goat milk formulas if your little one shows problems digesting cow’s milk-based formulas but is not diagnosed with CMPA (Cow’s Milk Protein Allergy). Goat milk proteins are often considered easier to digest than cow’s milk proteins. *Read: Nannycare vs Kendamil Goat
Last Words
We hope this comparison between Enfamil Reguline and Similac 360 has helped you solve your doubts.
Before you make any purchasing decisions, we strongly recommend you to read about the alternatives above.
If you need further assistance, leave a comment and we’ll get back to you in less than 24 hours.
Happy feeding!
We’re Maria and Alberto, a married couple and educators who are nutrition enthusiasts. Even before we had kids, we were already crazy about nutrition.
We’d read scientific articles, watch videos from nutritionists, and spend hours listening to nutrition podcasts.
Today, we continue doing this, but in a different way, as we’ve learned to sift through the noise and trends. Nutrition, like any other field of knowledge, the more you read and learn, the more you develop a comprehensive understanding of reality, and that’s what has happened to us.
Before having our first child, we focused on learning everything we could about child nutrition, using the same techniques we had already employed, backed by our extensive knowledge in nutrition.
Our mission is to help other parents with their children’s nutrition, to help them become the best versions of themselves.
If we are what we eat and drink, which is absolutely true, let’s do it right!
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