Key Differences Between Enfamil Reguline and Neuropro Gentlease
| Feature | Enfamil Reguline | Enfamil Neuropro Gentlease |
|---|---|---|
| ✅ Main Focus | Relieves constipation | Eases fussiness, gas, and spit-up |
| Protein Source | Partially hydrolyzed nonfat milk and whey protein concentrate solids (soy) | Partially hydrolyzed nonfat milk and whey protein concentrate solids (soy) |
| Carb Source | Corn syrup solids and lactose | Corn syrup solids (Lactose-free) |
| Fat Source | Various vegetable oils and Crypthecodinium Cohnii Oil (Omega-3 DHA) | Various vegetable oils, Schizochytrium sp. oil (Omega-3 DHA), and MFGM |
| Brain Development Nutrients | DHA and Choline | DHA and MFGM |
| Prebiotics & Probiotics | Contains dual prebiotics (Galactooligosaccharides and Polydextrose) | Does not contain prebiotics or probiotics |
| Usage | Suitable for babies up to 12 months old | Suitable for babies up to 12 months old |
| Country of Origin | Made in the USA | Made in the USA |
| Purchase Options | Buy Enfamil Reguline at Target / Buy Enfamil Reguline at Walmart | Buy Enfamil Neuropro Gentlease at Target / Buy Enfamil Neuropro Gentlease at Walmart |
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This article aims to compare two popular formulas for sensitive babies in the US: Enfamil Reguline vs Enfamil Neuropro Gentlease.
We will analyze their ingredients and nutritional information to help you make an informed decision for your baby.
Let’s get after it!
*Related read: Enfamil Reguline vs Nutramigen
Our Short Answer
Another fairly close comparison, but here’s our decision.
Enfamil Neuropro Gentlease is the winner in this comparison, thanks to one ingredient: MFGM (Milk Fat Globule Membrane). This fatty acid has a lot of benefits for babies (see below).
Although Enfamil Reguline has prebiotics and Neuropro Gentlease does not, this fact does not carry enough weight to make it the winner.
Having said all this, we recommend you learn about the alternatives below before deciding.
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Overview of the two formulas
Enfamil Reguline addresses constipation with easy-to-digest proteins, prebiotics, and nutrients for brain and immune development.
Neuropro Gentlease tackles gas and fussiness, with clinically proven relief within 24 hours.
Both provide complete nutrition and brain-building Omega-3 DHA, suitable for babies up to 12 months old.
Enfamil Reguline
Enfamil Reguline is designed to offer complete nutrition for your baby while addressing the constipation issue some infants struggle with.
This formula contains a blend of easy-to-digest proteins and prebiotics proven to produce softer, comfortably passing stools within the first week of use. It also has dual prebiotics, promoting gut health which contributes to healthier poop.
Reguline includes nutrients like Omega 3 DHA, vitamins, and 30 other nutrients that complement your baby’s diet and support healthy brain development and immune function.
It’s gentle enough to be used daily and is suitable for babies through their first 12 months.
Enfamil Neuropro Gentlease
Enfamil Neuropro Gentlease takes a slightly different approach by addressing common digestive discomforts issues such as gas and fussiness.
This formula is clinically proven to reduce these issues within 24 hours of use—a relief, no doubt, for many concerned parents.
One standout feature of Neuropro Gentlease is its brain-building Omega-3 DHA, that’s in the quantity global experts recommend.
This quantity of Omega-3 DHA has earned this product the “#1 recommended formula brand” by pediatricians tag.
Enfamil Neuropro Gentlease also boasts complete nutrition for babies up to 12 months old, with easy-to-digest proteins and essential vitamins and minerals for overall growth and immune health.
Nutritional Composition
Enfamil Reguline and Neuropro Gentlease have partially hydrolyzed proteins from nonfat milk and whey concentrate (soy).
Both use corn syrup solids as the primary carbohydrate source. Reguline includes lactose, while Gentlease is lactose-free.
Both contain various vegetable oils and omega-3 DHA sources.
Gentlease stands out for adding MFGM, which is beneficial for brain development, immune health, and more.
Protein Content
Protein is crucial for babies as it plays a key role in their growth and development.
Enfamil Reguline and Enfamil Neuropro Gentlease’s protein source is partially hydrolyzed nonfat milk and whey protein concentrate solids (soy).
This form of protein is easy to digest for babies, making it a beneficial ingredient.
The amount of protein per serving (5 fl oz) for both formulas is 2.3g.
Both formulas have the exact type of protein: partially hydrolyzed. Learn more here.
This means the protein is partially broken down (pre-digested), making it easy for babies with issues to process without issues.
Carbohydrate Content
Carbohydrates provide the energy required for your baby’s daily activities and cognitive development.
Both Enfamil Reguline and Neuropro Gentlease formulas use corn syrup solids as the primary carbohydrate source, with lactose also present in Enfamil Reguline.
The carbohydrate amount per serving in Enfamil Reguline is 11.1g while it is 10.8g for Enfamil Neuropro Gentlease.
The main difference in carb content is that Enfamil Reguline adds a bit of lactose to its formula.
This means that if your baby has a severe lactose intolerance, Neuropro Gentlease is a better option, since it has no lactose.
Otherwise, Reguline should be your choice, because lactose is the best carbohydrate for infant formula, which is present in breast milk.
Fats and Oils
Healthy fats are an essential part of a baby’s diet because they support brain development, aid in nutrient absorption, and provide necessary energy.
The fats in these two formulas come from various vegetable oils, including palm olein, coconut, soy, and high oleic sunflower oils.
Additionally, the formula includes specialized oils like Mortierella Alpina oil, a source of arachidonic acid (ARA), a useful omega-6 fatty acid.
Furthermore, both products contain Omega-3 DHA derived from Crypthecodinium Cohnii Oil for Enfamil Reguline, while the DHA in Enfamil Neuropro Gentlease comes from Schizochytrium sp. oil.
Your baby needs these omega-3 fatty acids for brain and eye development.
Per serving (5fl oz), both formulas contain 5.3g of fat which include essential fatty acids beneficial to babies like linoleic acid at 780mg.
Enfamil Neuropro Gentlease adds MFGM or Milk Fat Globule Membrane, a highly beneficial fatty acid found in breast milk.
Even though both formulas have different sources of DHA, they provide the same benefits, and there are no important differences between them in terms of bioavailability and benefits for babies.
The main difference in fat content is the fact that Enfamil Neuropro Gentlease adds MFGM. This ingredient has proven to be extremely beneficial for babies:
- Supports cognitive development: MFGM helps support your baby’s brain structure and function, which can help with learning and thinking
- Supports immune health: MFGM can help protect babies from getting sick by supporting their immune system
- Decreases ear infections: MFGM can help decrease the chance of babies getting ear infections, which can be painful
- Positive effects on intestinal development: MFGM can help protect babies from harmful toxins and can be especially helpful for babies born prematurely
- Narrows the gap between breastfed and formula-fed infants: Adding MFGM to formula can help make it more like breast milk and give babies some of the same benefits as breastfed babies
Probiotics and Prebiotics
Enfamil Reguline includes dual probiotics (Galactooligosaccharides and Polydextrose) to support gut health and digestion.
Enfamil Neuropro Gentlease, however, lacks prebiotics and probiotics in its formula.
Friendly bacteria known as probiotics and their favorite food, prebiotics, can boost the overall health of your baby’s tummy.
They are critical in establishing healthy gut flora, improving digestion, and bolstering the immune system. *Learn more: Prebiotics and probiotics in baby formula
Enfamil Reguline incorporates a dual probiotic blend in its formulation (Galactooligosaccharides and Polydextrose), supporting gut health for better digestion and softer stools.
Enfamil Neuropro Gentlease formula does not contain prebiotics or probiotics in its ingredient list.
Best Places to Buy Enfamil Reguline and Enfamil Gentlease
Enfamil Reguline
Enfamil Neuropro Gentlease
Buy Enfamil Gentlease at Target
Buy Enfamil Gentlease at Walmart
What are the best alternatives to Enfamil Reguline and Enfamil Neuropro Gentlease?
Even though Reguline and Neuropro Gentlease are perfectly fine formulas, there are better and more natural formulas in the market. Here are our favorites for babies with tummy issues:
Hipp HA: This hypoallergenic formula is an excellent option for babies prone to allergies. It contains hydrolyzed proteins, uses organic ingredients, and has a powerful blend of prebiotics and probiotics to support digestive health. *Read: Hipp HA vs Gentlease
Hipp AR and Comfort: These are specially formulated for babies intolerant to lactose, which can often cause tummy issues like bloating or diarrhea. They contain reduced lactose content compared to other formulas, organic ingredients, prebiotics, and probiotics. *Read: Hipp AR vs Comfort
Kendamil or Kabrita Goat Milk Formulas: If your baby has challenges digesting cow’s milk protein but doesn’t have Cow’s Milk Protein Allergy (CMPA), goat milk-based formulas might be an excellent fit. Brands such as Kendamil or Kabrita offer high-quality goat milk formulas known for being gentle on little tummies while providing necessary nutrition. *Read: Kendamil vs Kabrita
Last Words
We hope this comparison between Enfamil Reguline and Enfamil Neuropro Gentlease has helped you make an informed decision.
We strongly encourage you to read about the alternatives above before deciding.
If you have further questions, leave a comment, and we’ll get back to you in no time.
Happy feeding!
We’re Maria and Alberto, a married couple and educators who are nutrition enthusiasts. Even before we had kids, we were already crazy about nutrition.
We’d read scientific articles, watch videos from nutritionists, and spend hours listening to nutrition podcasts.
Today, we continue doing this, but in a different way, as we’ve learned to sift through the noise and trends. Nutrition, like any other field of knowledge, the more you read and learn, the more you develop a comprehensive understanding of reality, and that’s what has happened to us.
Before having our first child, we focused on learning everything we could about child nutrition, using the same techniques we had already employed, backed by our extensive knowledge in nutrition.
Our mission is to help other parents with their children’s nutrition, to help them become the best versions of themselves.
If we are what we eat and drink, which is absolutely true, let’s do it right!
