Enfamil-AR-vs-Enfamil-Neuropro-Gentlease

Key Differences Between Enfamil AR and Neuropro Gentlease

Baby FormulaEnfamil AREnfamil Neuropro Gentlease
Target IssuesReflux or frequent spit-upFussiness, gas, and spit-up
Main IngredientNonfat milk and rice starchPartially hydrolyzed nonfat milk and whey protein
Protein2.5g2.3g
CarbohydratesLactose, maltodextrin, rice starchCorn syrup solids
FatsFrom vegetable oilsFrom vegetable oils and MFGM
DHA✔️✔️
Probiotics and PrebioticsDual prebioticsGOS from corn syrup solids
Lactose Intolerance Friendly✔️
SuitabilityBabies with reflux or spit-up, no lactose intoleranceBabies with difficulty digesting cow’s milk protein, lactose intolerant babies

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This article aims to compare two popular formulas for sensitive babies: Enfamil AR (Anti-Reflux) vs Enfamil Neuropro Gentlease.

We will analyze their ingredients and nutritional compositions to give you the information you need to make an informed decision.

Let’s get started!

*Related: Enfamil AR vs Similac Alimentum

Our Short Answer

After analyzing both formulas, we cannot choose an absolute winner as they are designed for different conditions.

Choose Enfamil AR if your baby:

– Suffers from reflux or spit-up.
– Does not have allergy or difficulty digesting cow’s milk protein
– Does not suffer from lactose intolerance or lactose sensitivity

Choose Enfamil Neuropro Gentlease if your baby:

– Needs a hypoallergenic formula because he/she has difficulty digesting cow’s milk protein (If your baby is diagnosed with CMPA, then you should look for an extensively hydrolyzed formula)
– Suffers from lactose intolerance or lactose sensitivity


If you are unsure of your baby’s symptoms, consult your pediatrician. If this is not possible, we recommend trying Enfamil AR first, and if after about three days it does not go well, switch to Neuropro Gentlease.

That said, we recommend you explore the alternatives mentioned below.

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Overview of the two formulas

Enfamil AR reduces frequent spit-up by over 50% with rice starch, adhering to AAP reflux reduction guidelines. Contains DHA for brain and eye development, and dual prebiotics for immune health. Suitable for babies up to 12 months.

Enfamil Neuropro Gentlease addresses fussiness, gas, and spit-up, with recommended Omega-3 DHA for brain development. Complete nutrition for babies up to 12 months with easy-to-digest proteins and essential vitamins for immune health.

Enfamil AR

Enfamil AR is specially designed to benefit babies who frequently spit-up.

This formula aims to be clinically proven to decrease spit-up by over 50% within a week, satisfying the American Academy of Pediatrics’ reflux reduction guidelines.

Primarily made with rice starch, it thickens in your baby’s stomach, making it easier to digest and lessening frequent spit-ups.

It comes with brain-nourishing DHA that aids brain and eye development, which is essential for growing infants.

Enfamil AR also includes dual prebiotics to boost your baby’s immune system health.

It offers full nutrition tailored for your baby during their first 12 months.

Enfamil Neuropro Gentlease

Distinguished for its effectiveness in mitigating fussiness, crying, gas, and spit-up within 24 hours of use, Enfamil Neuropro Gentlease is an excellent option for gassy or fussy babies.

The formula boasts brain-building Omega 3 DHA in the amount recommended by global experts.

Alimentum ensures complete nutrition for babies up to 12 months and includes easy-to-digest proteins along with vitamins and minerals crucial for immune health.

Nutritional Composition

Enfamil AR has 2.5g protein from nonfat milk, while Neuropro Gentlease has 2.3g from partially hydrolyzed nonfat milk and whey protein concentrate solids for sensitive tummies.

AR uses lactose, maltodextrin, and rice starch for carbohydrates, better for reducing spit-up.

Gentlease uses corn syrup solids, suitable for lactose-intolerant babies.

Both formulas contain fats from vegetable oils, including palm olein, with Neuropro Gentlease having MFGM, which is beneficial for babies. 

Protein Content

In Enfamil AR, protein is sourced from nonfat milk and amounts to 2.5g per serving. Protein is essential for your baby’s growth and development.

On the other hand, Enfamil Neuropro Gentlease offers slightly less protein, with a total of 2.3g per serving. This formula uses partially hydrolyzed nonfat milk and whey protein concentrate solids as sources, making it easier for sensitive tummies to digest than full proteins.

For babies with problems digesting cow’s milk-based formulas, Neuropro Gentlease is your best bet, since it uses partially hydrolyzed milk, meaning its protein is pre-digested to make it easier for babies to process. 

*Learn more: Hydrolyzed formulas

Enfamil AR uses common skimmed milk, the standard for conventional formulas. 

Carbohydrate Content

Enfamil AR offers 11.3g of carbohydrates per serving, sourced from lactose, maltodextrin, and rice starch. Rice Starch in particular contributes largely to reducing spit-up in babies.

Enfamil Neuropro Gentlease contains slightly lesser carbohydrates, with 10.8g per serving derived from corn syrup solids. Chicory root-derived GOS is a carbohydrate source acting as a prebiotic aiding digestion.

Technically speaking, Enfamil AR has better carb sources than Neuropro Gentlease.

Gentlease uses corn syrup solids, a common alternative to lactose in US-based formulas. However, this carb source has more sugar, and it is sweeter than other carb sources.

*Learn more: Corn syrup in baby formula

AR uses lactose, the sugar found in breast milk, and then maltodextrin and rice starch, two more neutral sources of carbs that thicken the formula to help with reflux and spit-up.

*Learn more: Maltodextrin in baby formula and Starch in baby formula

Having said this, Neuropro Gentlease is a better option if your baby is lactose intolerant because it avoids lactose altogether.

Fats and Oils

Enfamil AR has 5.1g of fats per serving coming from sources such as vegetable oil (palm olein, coconut, soy), high oleic sunflower oils, and Mortierella Alpina Oil which is a source of Arachidonic Acid (ARA). This omega-6 fat is crucial for brain development.

Enfamil Neuropro Gentlease, on the other hand, contains slightly more fats at around 5.3g per serving sourced from similar vegetable oils along with MFGM (Milk Fat Globule Membrane). Both ARA present in Mortierella Alpina Oil and DHA present in Schizochytrium Sp Oil play a crucial role in neural development.

The main difference between the two formulas is that Neuropro Gentlease includes MFGM or Milk Fat Globule Membrane, a fatty acid found in breast milk that is highly beneficial for babies.

However, we do not like that both formulas use palm olein, a more processed version of palm oil.

Including this ingredient is controversial because it has been found to impede calcium absorption in studies.

*Learn more: Palm oil in baby formula

Probiotics and Prebiotics

Enfamil AR contains dual prebiotics, Galactooligosaccharides (GOS), and Polydextrose, promoting a healthy gut microbiome.

Enfamil Neuropro Gentlease includes GOS derived from corn syrup solids.

No probiotics in either formula.

In the case of Enfamil AR, it uses dual prebiotics Galactooligosaccharides (or GOS) and Polydextrose.

Prebiotics are food for beneficial gut bacteria, helping them colonize the gut effectively. In particular, GOS mimics the function of human milk oligosaccharides in breast milk, contributing to a healthy microbiome.

Enfamil AR doesn’t list specific probiotics in its ingredient list. 

Enfamil Neuropro Gentlease, like its counterpart, does not mention any specific probiotics. As for prebiotics contain GOS derived from corn syrup solids, which can boost gut health by promoting a healthy colony of good bacteria.

Best Places to Buy Enfamil AR and Neuropro Gentlease

Target-Logo
Walmart-Logo

Enfamil AR 

Buy Enfamil AR at Target 

Buy Enfamil AR at Warlmart

Enfamil Neuropro Gentlease 

Buy Enfamil Gentlease at Target 

Buy Enfamil Gentlease at Walmart

What are the best alternatives to Enfamil Anti-Reflux and Enfamil Neuropro Gentlease?

Even though these two formulas are good options, there are better products on the market. Here are our recommended alternatives:

For Enfamil AR:

  • Hipp Comfort: An organic formula that is specially designed to soften baby’s stool, promote healthy digestion, and ease colic symptoms. Just like Enfamil AR, it uses starch but in a smaller quantity. 

  • Hipp Anti-Reflux: Another organic option from Hipp specifically designed for babies with reflux and regurgitation. It contains similar components to Enfamil AR formula, like prebiotics for digestive health. An added feature is locust bean gum, a natural thickener that helps keep the milk from coming back up. *Read: Hipp Comfort vs Hipp AR

For Enfamil Neuropro Gentlease:

  • Hipp HA: Also an organic formula like Hipp Comfort and Anti-Reflux. However, its hydrolyzed protein constituents set it apart, making it suitable for infants sensitive to intact proteins. Plus, it possesses a potent blend of prebiotics and probiotics, closely resembling those found in Neuropro Gentlease. *Read: Hipp HA vs Enfamil Gentlease

Last Words

We hope this comparison between Enfamil Anti-Reflux and Enfamil Neuropro Gentlease has helped you make an informed decision.

We strongly encourage you to learn about the alternatives above before making any purchasing decisions.

Happy feeding!

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