7 Best Infant Formula Alternatives to Similac 360 Total Care

In this article, you will find seven Similac 360 Total Care alternatives carefully chosen and that offer similar or better benefits for your baby’s nutrition.

The list starts with four US formulas, which are more readily available, and ends with three organic European formulas, which we consider to be among the best formulas in the world.

Let’s get after it!

*Related read: Enfamil Gentlease Alternatives

OUR SHORT ANSWER: BEST Similac 360 Total Care Alternatives

Alternative	Key Differences	Which Is Better?
Similac Pure Bliss	– Contains only one prebiotic: galactooligosaccharides. – Milk sourced from Irish farms. – Contains Schizochytrium sp. oil as a DHA source.	Pure Bliss due to its more natural and purer milk origin.
Similac Pro-Advance	– Contains only one type of HMO: 2’FLMO.	Similac 360 Total Care due to its variety of HMOs.
Enfamil Neuropro	– Offers MFGM for cognitive development. – Contains palm olein oil.	Similac 360 Total Care due to its absence of controversial ingredients and richer HMO blend.
Bobbie	– Uses grass-fed milk from Organic Valley®. – Emphasizes organic, non-GMO ingredients. – Has a plant-based oil blend.	Bobbie, considering its organic ingredients, grass-fed milk source, and simplified ingredient list.
Kendamil Organic	– Uses naturally occurring HMOs: 3’-GL, 4’-GL, and 6’-GL. – Sourced from Red tractor farms. – Contains Milk Fat Globule Membrane (MFGM).	Kendamil Organic for its organic milk, real HMOs, and presence of MFGM.
Hipp Dutch	– Contains a natural probiotic culture. – Certified EU organic. – Sourced from biodynamic farms. – Free from artificial sweeteners & GMOs.	Hipp Dutch due to its organic composition and high-quality ingredient sourcing.
Holle Bio	– Doesn’t specifically list prebiotics. – Uses palm, sunflower, and rapeseed oil. – Adopts organic and biodynamic farming practices.	Holle Bio 1 for its high-quality, organic, and ethically sourced ingredients, and biodynamic farming practices.

Recommendation: Kendamil Organic is our top recommendation due to the use of whole milk, organic ingredients and the addition of MFGM and HMOs.

Similac 360 Total Care Features and Ingredients

• Base Ingredients: Nonfat Milk, Lactose, High Oleic Safflower Oil, Whey Protein Concentrate, Soy Oil, and Coconut Oil.
• Prebiotics: Contains a blend of five Human Milk Oligosaccharides (HMOs) including 2′-Fucosyllactose, Lacto-N-Tetraose, 3-Fucosyllactose, 6′-Sialyllactose, and 3′-Sialyllactose. These HMOs are not derived from human milk but are structurally identical to those in breast milk.
• Omega Fatty Acids: C. Cohnii Oil (source of DHA) and M. Alpina Oil (source of ARA) to support brain development.
• Digestive and Immune Support: Apart from HMO prebiotics, the formula contains nucleotides that aid in digestive health and immune support.
• No Artificial Growth Hormones: The formula does not contain artificial growth hormones. It’s important to note that there’s no significant difference between milk from rbST-treated and non-rbST-treated cows.
• Non-GMO: Ingredients in Similac 360 Total Care are not genetically engineered, ensuring a natural formula for your infant.

ALTERNATIVE 1: Similac Pure Bliss

Similarities

The foundational ingredients in both formulas include nonfat milk, lactose, vegetable oils (high oleic safflower oil in 360 Total Care and high oleic sunflower oil in Pure Bliss), whey protein concentrate, soy oil, and coconut oil.

Both formulas contain essential vitamins and minerals like Ascorbic Acid (Vitamin C), Niacinamide (Vitamin B3), and Calcium Pantothenate.

Differences

Similac 360 Total Care features an exclusive blend of five human milk oligosaccharides structurally identical to those found in breast milk, which aids immune, brain, and digestive health.

Similac Pure Bliss only includes one prebiotic – galactooligosaccharides.

Similac 360 Total Care is primarily sourced from domestically supplied ingredients.

Similac Pure Bliss sources its milk from family-owned Irish farms where cows are free to graze outdoors all day.

Both offer DHA and ARA for brain and eye development, but Schizochytrium sp. oil (source of DHA) is present only in Pure Bliss.

Which One Is Better?

In our opinion, Pure Bliss is a better formula because the origin of the milk they use is purer and more natural.

Even though 360 Total Care adds five different HMOs, it is not enough benefit to outperform Pure Bliss’ free-range milk.

*Learn more: Similac Pure Bliss vs 360 Total Care

ALTERNATIVE 2: Similac Pro-Advance

Similarities

Similac Pro-Advance and Similac 360 Total Care share many common ingredients, such as nonfat milk, lactose, high oleic safflower oil, whey protein concentrate, soy oil, and coconut oil.

Both have Ascorbic Acid for a strong immune system, Niacinamide for good digestion, and Calcium Pantothenate for healthy growth.

Differences

Similac 360 Total Care boasts an exceptional blend of five human milk oligosaccharides known as HMOs (structurally identical to those found in breast milk), which support a healthy immune system, brain health, and digestive health.

On the other hand, Similac Pro-Advance adds only one type of HMO—2’FLMO—which means it has fewer beneficial bacteria food than 360 Total Care.

Which One Is Better?

The nutritional profiles of Similac Pro-Advance and 360 Total Care are nearly identical—they use the same ingredient sources and have almost the same amounts of macro and micronutrients.

Our pick here is Similac 360 Total Care thanks to its five different types of HMOs compared to only one in Pro-Advance.

*Learn more: Similac Pro-Advance vs 360 Total Care

ALTERNATIVE 3: Enfamil Neuropro

Similarities

Enfamil Neuropro shares some common ingredients with Similac 360 Total Care, such as nonfat milk, lactose, and vegetable oils like soy and Coconut. They also include essential vitamins C, B3 and Calcium Pantothenate in their formula.

Both formulas contain whey protein concentrate and a source of ARA (Arachidonic Acid) and DHA (Docosahexaenoic Acid), which are important for the baby’s brain development.

Differences

Similac 360 Total Care features five structurally identical human milk oligosaccharides (HMOs).

Enfamil Neuropro offers a fat-protein blend of MFGM (Milk Fat Globule Membrane) which could foster cognitive development and immune support as per clinical studies.

Enfamil Neuropro uses palm olein, a controversial vegetable oil, while Similac’s formula does not.

Which One Is Better?

Similac 360 Total Care has an edge over Enfamil Neuropro. The reason is Similac 360’s absence of any controversial ingredients like palm oil derivatives and its unique blend of five types of HMOs – the most beneficial prebiotics found in breast milk.

*Learn more: Enfamil Neuropro vs Similac 360 Total Care

ALTERNATIVE 4: Bobbie

Similarities

Similac 360 Total Care and Bobbie incorporate skimmed milk, lactose, vegetable oils, and whey protein concentrate. Their formulas include a blend of high oleic safflower or sunflower oil, canola oil, and coconut oil.

Both brands add essential vitamins and minerals to their formula for proper infant growth.

Differences

While Similac 360 Total Care is recognized for its exclusive blend of five human milk oligosaccharides to bolster immune, brain, and digestive health, Bobbie goes for a more natural approach using grass-fed milk from pasture-raised cows across the U.S through Organic Valley® – a cooperative model of family-owned farms.

Unlike Similac 360 Total Care’s primarily domestically sourced ingredients, Bobbie emphasizes organic and non-GMO ingredients – standing up to stringent testing by the Clean Label Project for contaminants.

Another vital difference is in the oil sources. While both offer DHA and ARA for brain and eye development derived from Schizochytrium sp. oil*, Bobbie enhances its formula through a plant-based blend of sunflower/safflower, coconut, and canola oils, which are expeller-pressed for safety without chemical solvents or high heat, which means they are less processed.

Which One Is Better?

Considering all aspects related to ingredient quality & sourcing methods – we lean towards Bobbie.

Why? Firstly, it’s the organic ingredients sourced from grass-fed cows that are happy and healthy; this ensures that your little one gets top-notch milk.

Secondly, Bobbie’s formula is inspired by breast milk’s protein ratio (60:40), an essential aspect for easy digestion.

Lastly, the pared-down ingredient list means fewer chances for potential allergens or fillers.

*Learn more: Bobbie vs 360 Total Care

ALTERNATIVE 5: Kendamil Organic

Similarities

Both formulas also contain Human Milk Oligosaccharides (HMOs), important for supporting a baby’s immune system.

Differences

Kendamil Organic sets itself apart from Similac 360 Total Care in several key areas. While they both feature HMOs, Kendamil goes out of its way to use naturally occurring ones. It’s the only formula in the market now that includes these types of HMOs—3’-GL, 4’-GL, and 6’-GL.

Another standout aspect of Kendamil Organic is its sourcing and production. Kendamil processes raw EU-certified organic milk into formula powder at their facilities, ensuring optimum vitamin and protein content. In contrast, the sources for Similac 360 Total Care’s ingredients are primarily domestic.

Kendamil Organic also focuses on using whole cream milk from happy cows, which adds Milk Fat Globule Membrane (MFGM) to its ingredients – the same found in breast milk known to aid in babies’ cognitive development.

Which One Is Better?

We recommend Kendamil Organic for several reasons:

1. It uses whole organic milk from certified Red tractor farms.
2. It includes Milk Fat Globule Membrane (MFGM) – known to boost babies’ cognitive development.
3. It has real HMOs that play an essential role in supporting infant immunity.
4. It has a 60:40 whey to casein protein ratio, suitable for easy digestion.

*Learn more: Kendamil Formula Review

ALTERNATIVE 6: Hipp Dutch

Similarities

Both Similac 360 Total Care and Hipp Dutch 1 have foundational ingredients like nonfat milk, lactose, and a variety of vegetable oils. Moreover, they contribute essential vitamins and nutrients necessary for your baby’s health such as Vitamin C, B3, calcium, and even DHA for better brain and eye development.

Just like Similac, Hipp includes prebiotics (galactooligosaccharides / GOS).

Differences

Hipp includes a natural probiotic culture extracted from breast milk (Limosilactobacillus fermentum hereditum®2), which plays a vital role in supporting healthy intestinal flora in babies.

Moreover, Hipp formulas are certified EU organic – a promise that the milk used comes from farms with high standards of animal welfare and environmentally sustainable practices devoid of any chemical fertilizers or pesticides. Unlike Similac’s domestically sourced ingredients, Hipp Dutch carefully sources its ingredients from biodynamic farms.

Additionally, the Hipp Dutch formula brings additional peace of mind as it is free from artificial sweeteners and GMOs; it does not contain any allergens including gluten, soy, peanuts or eggs – factors not specified or guaranteed by Similac Total Care.

Unlike Similac with five different human milk oligosaccharides (meant to mimic breast milk), Hipp contains naturally occurring prebiotics and probiotics similar to those found in actual human breast milk.

Which One Is Better?

From our perspective, while both formulas have their merits, Hipp Dutch 1 takes the lead. The primary reason for this choice is the organic composition of Hipp and its careful sourcing from biodynamic farms with high animal welfare standards.

*Learn more: Hipp vs Similac

ALTERNATIVE 7: Holle Bio

Similarities

• Both formulas are based on nonfat milk, making them quite similar at first glance.
• The source of protein in both is from whey products: whey protein concentrate in Similac 360 Total Care and partially demineralized whey powder in Holle Bio 1.
• Both include essential nutrients like calcium carbonate, potassium chloride, iron sulfate, zinc sulfate etc., vital for the growth and development of your baby.
• The inclusion of fatty acids from microalgae oil (Schizochytrium sp.)

Differences

• Similac 360 Total Care offers an exclusive blend of five human milk oligosaccharides structurally identical to those found in breast milk, aiding immune function, brain health, and digestive health.
• Vegetable oils show up in the list of ingredients for both brands. While Similac uses high oleic safflower oil, Holle uses palm, sunflower, and rapeseed oil.
• In contrast, Holle Bio doesn’t highlight having specific prebiotics. However, it assures no artificial sweeteners or genetically modified organisms (GMOs) in their formula.
• An organic and biodynamic approach distinguishes Holle Bio1 — its formula includes Demeter-certified organic skimmed milk sourced through eco-friendly and animal welfare-conscious farming practices.
• Unlike Similac 360 Total Care, which primarily sources ingredients domestically, Holle Bio 1 is European.

Which One Is Better?

Holle Bio 1 would be our choice. We value the use of organic and ethically sourced ingredients very highly; when it comes to infant nutrition, the quality of ingredients is paramount. We also believe in the added value of their biodynamic farming practices for maintaining the integrity of their ingredients.

*Learn more: Holle vs Similac

LAST WORDS and Our Favorite Formula

And there you have it. Whether you need an alternative to Similac 360 Total Care because your baby is not correctly responding to the formula or because you want to try other formulas, this list of 7 formulas like Similac 360 is more than enough to choose the perfect alternative.

If we had to choose one formula amongst the alternatives, we would go for Kendamil Organic. After many articles comparing Kendamil against other formulas, there has not been one that matches Kendamil’s quality.

We hope this article helps you, and if you have any other questions, feel free to ask them in the comments or contact us through the form on our homepage.

Happy feeding!