Key Differences Between Enfamil Neuropro Gentlease and Similac Pro-Total Comfort
| Enfamil Neuropro Gentlease | Similac Pro-Total Comfort | |
|---|---|---|
| Proteins | Partially Hydrolyzed | Partially Hydrolyzed |
| Carbohydrates | Corn Syrup Solids | Corn Maltodextrin & Sugar |
| Fats and Oils | Includes Palm Olein & MFGM | No Palm Olein |
| GMOs | Non-GMO | Non-GMO |
| Prebiotics | No | Yes (2′-FL HMO) |
| Probiotics | No | No |
| DHA and Lutein | Yes | Yes |
| Immune Support | Yes (MFGM) | Yes (2′-FL HMO) |
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Choosing the right baby formula that ensures optimum nutrition and comfort for your little one is crucial.
You are in the right place if you are considering Enfamil Neuropro Gentlease and Similac Pro-Total Comfort!
This in-depth comparison of ‘Enfamil Neuropro Gentlease vs Similac Pro-Total Comfort’ will highlight the nutritional composition, ingredients, benefits, and drawbacks of each one and help make your choice easier.
Let’s get after it!
*Related reads: Enfamil Gentlease vs Similac Pro-Total Comfort | Enfamil Gentlease vs Enfamil Neuropro Gentlease
Our Short Answer
In our comparison between Enfamil Gentlease (the non-Neuropro version) and Similac Pro-Total Comfort, we chose the latter, but with the Neuropro version, we changed our opinion.
We believe that Neuropro deserves the victory for the simple fact of adding MFGM (Milk Fat Globule Membrane).
This complex structure positively affects brain development, metabolic response, and gut health. It has also demonstrated antiviral activity and a reduction in the incidence of diarrhea.
Here are the pros and cons of each.
Enfamil Neuropro Gentlease:
+++ Adds MFGM
+ No added sugars
– No prebiotics
– Uses Corn Syrup Solids
– Adds Palm OleinSimilac Pro-Total Comfort
+ Adds 2′-FL HMO, a prebiotic found in breast milk
+ Uses Corn Maltodextrin instead of Syrup Solids
— Adds extra sugars
Please note that this is our personal opinion. Similac Pro-Total Comfort is still a formula with excellent features.
Before deciding, we recommend looking at the alternatives (further down in the article).
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Overview of the Two Formulas
Enfamil NeuroPro Gentlease eases fussiness and includes Omega 3 DHA and MFGM.
Similac Pro-Total Comfort is for babies with fussiness and gas, contains 2’FL HMO for the immune system, and does not include palm olein oil.
Both formulas include essential nutrients for brain and eye health.
Enfamil Neuropro Gentlease
Enfamil NeuroPro Gentlease is a popular baby formula clinically proven to ease fussiness, gas, crying, and spit-up within 24 hours of use.
It features Omega 3 DHA in amounts recommended by global experts for brain-building nutrition.
It is available in powder and liquid forms with various size options.
Its complete nutrition makes it suitable for babies up to 12 months.
Along with easy-to-digest proteins, Enfamil NeuroPro Gentlease includes vitamins and minerals that boost immune health as well as Milk Fat Globule Membrane.
Similac Pro-Total Comfort
Similac Pro-Total Comfort is an easy-to-digest formula for babies with fussiness, gas, and crying who struggle to tolerate other milk-based formulas.
This formula contains immune-nourishing prebiotic like 2′-FL HMO, which is found in breast milk and supports a baby’s developing immune system.
Unlike many other baby formulas on the market, Similac Pro-Total Comfort doesn’t contain palm olein oil, enabling excellent calcium absorption.
It also includes DHA and lutein—essential ingredients found in breast milk—that support brain and eye health.
Nutritional Composition
Enfamil NeuroPro Gentlease and Similac Pro-Total Comfort both use partially hydrolyzed proteins.
Enfamil NeuroPro Gentlease has a whey-to-casein ratio of 60:40, while Similac Pro-Total Comfort has a ratio of 48:52.
Enfamil NeuroPro Gentlease contains carbohydrates sourced from corn syrup solids, while Similac Pro-Total Comfort uses corn maltodextrin and sugar.
Both formulas include a blend of fats and oils, but Enfamil NeuroPro Gentlease includes palm olein and MFGM, while Similac Pro-Total Comfort does not have palm olein but also does not add MFGM.
Protein Content
Enfamil NeuroPro Gentlease: The protein content in Enfamil NeuroPro Gentlease per 100 calories is 2.3g. This formula uses partially hydrolyzed nonfat milk and whey protein concentrate solids as their primary source of protein. These proteins are easier on the infant’s tummy and thus help in reducing fussiness and gas.
Similac Pro-Total Comfort: The protein content in Similac Pro-Total Comfort per serving size of 5 fl oz is 2.32g, prepared as directed. Their primary source of protein is whey protein hydrolysate, intended for babies who have difficulty tolerating other milk-based formulas.
Both formulas use partially hydrolyzed protein, which means it is easier to digest since it is partially broken down.
This type of protein is perfect for babies who have problems digesting cow’s milk protein.
However, if your baby has CMPA, you should look for an extensively hydrolyzed formula.
Enfamil has a better whey-to-casein ratio of 60:40, while Similac has 48:52.
*Learn more: Extensively hydrolyzed vs partially hydrolyzed formulas
Carbohydrate Content
Enfamil NeuroPro Gentlease: This formula contains carbohydrates at 10.8g per 100 calories, sourced primarily from corn syrup solids which function as a sweetener and provide an easy-to-digest carb source for babies.
Similac Pro-Total Comfort: Similac Pro-Total Comfort provides 10.7g worth of carbohydrates per serving of 5 fl oz (prepared as directed), with the primary sources being corn maltodextrin (a digestible carbohydrate made from corn) and sugar.
Corn maltodextrin is a better choice than corn syrup solids because it has less sugar. So, you might think Pro-Comfort, which uses maltodextrin, is better.
But there’s a twist. Pro-Comfort adds extra sugar to the mix to make the formula taste better. That’s not the best thing to do, because baby formula should taste as plain as possible.
So, there’s no clear winner when we talk about the sugar part of these two formulas. Enfamil Neuropro Gentlease and Similac Pro-Comfort are pretty much tied.
*Learn more: Corn Syrup in Baby Formula
Fats and Oils
Enfamil NeuroPro Gentlease: The fat content in this formula is at 5.3g per 100 Calories, derived from a mix of vegetable oil (Palm Olein, Coconut, Soy, And High Oleic Sunflower Oils). Other added sources are Mortierella Alpina Oil, which is a source of Arachidonic Acid (ARA), and Schizochytrium Sp. Oil used as a source of Docosahexaenoic Acid (DHA). It also adds MFGM (Milk Fat Globule Membrane), which is highly beneficial.
Similac Pro-Total Comfort: This formula contains approximately 5.4g fat per serving size of 5 fl oz, (prepared as directed). The fats in this formula come from High Oleic Safflower Oil, Soy Oil, Coconut Oil. It also has the same sources of DHA and ARA as Neuropro Gentlease.
Enfamil Neuropro Gentlease has palm olein (a more processed version of palm oil). The only instance where we would not mind the addition of palm oil to infant formula is if it were of organic origin.
That said, Enfamil Neuropro Gentlease also adds MFGM, an ingredient found in breast milk that consists of a membrane surrounding fat molecules that is highly bioavailable and easily absorbed by infants’ microbiota.
Similac Pro-Comfort does not have palm olein but also does not add MFGM.
We believe Enfamil’s addition of MFGM counteracts its use of palm olein, so we consider it a winner in fat content.
*Learn more: Palm Oil in Baby Formula
Probiotics and Prebiotics
Similac Pro-Total Comfort contains the prebiotic 2′-FL HMO.
Enfamil Neuropro Gentlease does not include prebiotics or probiotics in its formula.
While both Enfamil Neuropro Gentlease and Similac Pro-Total Comfort are designed to be gentle on baby’s stomach, only Similac Pro-Total Comfort includes a prebiotic—2′-FL HMO—in its ingredient list. This prebiotic, also found in breast milk, helps support the baby’s developing immune system.
Enfamil Neuropro Gentlease, on the other hand, does not include any prebiotics or probiotics in its formula.
Best Places to Buy Neuropro Gentlease and Pro-Total Comfort
Enfamil Neuropro Gentlease
Buy Enfamil Gentlease at Target
Buy Enfamil Gentlease at Warlmart
Similac Pro-Total Comfort
Buy Similac Pro-Total Comfort at Target
Buy Similac Pro-Total Comfort at Walmart
What are the best alternatives to Enfamil Neuropro Gentlease and Similac Pro-Total Comfort?
There are other formulas we would choose instead of Enfamil and Similac. Here are our personal recommendations:
Hipp HA: This hypoallergenic formula is partially hydrolyzed, making it easy to digest. It’s our top pick for infants with a high allergy risk. *Read: Hipp HA vs Enfamil Neuropro Gentlease
Hipp Comfort: Designed for babies with lactose sensitivities, this formula reduces lactose content and uses easily digestible fats and proteins to ease common digestion-related discomforts.
Hipp Anti-Reflux: Formulated to reduce reflux issues in babies, this specialist milk contains locust bean gum making it creamier and thicker than regular formulas. *Read: Hipp Comfort vs Anti-Reflux
Kendamil Goat or Nannycare: These goat milk-based formulas make excellent alternatives for babies having difficulty digesting cow’s milk formula. However, these formulas should not be used if your baby has Cow’s Milk Protein Allergy (CMPA) as cow’s and goat’s milk proteins are similar. *Read: Kendamil vs Nannycare
Last Words
We sincerely hope this comparison between Enfamil Neuropro Gentlease and Similac Pro-Total Comfort helps you make an informed decision.
We recommend you read about the alternatives above before you make a decision.
If you need further help or have extra questions, comment below, and we’ll get back to you in less than a day.
See you around!
We’re Maria and Alberto, a married couple and educators who are nutrition enthusiasts. Even before we had kids, we were already crazy about nutrition.
We’d read scientific articles, watch videos from nutritionists, and spend hours listening to nutrition podcasts.
Today, we continue doing this, but in a different way, as we’ve learned to sift through the noise and trends. Nutrition, like any other field of knowledge, the more you read and learn, the more you develop a comprehensive understanding of reality, and that’s what has happened to us.
Before having our first child, we focused on learning everything we could about child nutrition, using the same techniques we had already employed, backed by our extensive knowledge in nutrition.
Our mission is to help other parents with their children’s nutrition, to help them become the best versions of themselves.
If we are what we eat and drink, which is absolutely true, let’s do it right!
