Key Differences Between Enfamil Gentlease and Similac Pro-Total Comfort
| Enfamil Gentlease | Similac Pro-Total Comfort | |
|---|---|---|
| Proteins | Partially Hydrolyzed | Partially Hydrolyzed |
| Carbohydrates | Corn Syrup Solids | Corn Maltodextrin & Sugar |
| Fats and Oils | Includes Palm Olein | No Palm Olein |
| GMOs | Non-GMO | Non-GMO |
| Prebiotics | No | Yes (2′-FL HMO) |
| Probiotics | No | No |
| DHA and Lutein | Yes | Yes |
| Immune Support | No | Yes (2′-FL HMO) |
Blwstore is supported by its audience. When you buy through links on our site, we may earn an affiliate commission.
Choosing the perfect baby formula is difficult, even more, if your baby has a sensitive tummy.
This article will compare two US popular formulas, Enfamil Gentlease vs Similac Pro Total Comfort, to give parents the information they need to make the perfect decision for their baby.
Let’s get after it!
*Related reads: Enfamil Neuropro Gentlease vs Similac Pro Total Comfort | Enfamil Gentlease vs Neuropro Gentlease
Our Short Answer
If we had to choose between Enfamil Gentlease and Similac Pro-Total Comfort, we would choose the latter for the following two reasons:
1. It does not contain palm olein
2. It contains 2′-FL HMO, a prebiotic in breast milk that benefits the baby’s microbiota.Although Pro-Comfort adds sugar, the pros of this formula outweigh the cons, and compared to Gentlease, it is a better choice.
That said, there are other formulas that are more natural and that we recommend you try before Enfamil or Similac (see alternatives below).
With over 100,000 orders delivered globally since 2019, Organic's Best offers clean, safe, and nutritionally rich formulas and snacks.
Free shipping over $100, commitment to freshness and authenticity.
- Express delivery in 2 to 5 business days
- Sourcing from European manufacturers
- Minimum shelf life of 6 months
- Climate-Controlled Warehouse
Give your little one the best start.
CODE 'BLW' for a 5% discount in all orders
At BLWStore, we may earn a commission from some of the products featured on our website through affiliate partnerships with retailers. We want to be transparent with our readers and let you know that we do not receive any products for special consideration. The commission we earn helps support our website and allows us to continue providing helpful information and product recommendations. Thank you for your support!
Overview of the Two Formulas
Enfamil Gentlease is designed to manage fussiness and gas. It includes DHA for cognitive development, vegetable oils, and corn syrup solids. It is non-GMO.
Similac Pro-Total Comfort is easily digestible, and includes 2′-FL HMO for the immune system, partially hydrolyzed whey protein, corn maltodextrin, and sugar for carbohydrates. It also contains DHA, lutein, and is GMO-free.
Enfamil Gentlease
The Enfamil Gentlease formula is designed with fussiness, gas, and crying in mind.
Known for its all-in-one comfort, Gentlease aims to manage these common issues within 24 hours of its introduction to your baby’s diet.
For cognitive development, Gentlease contains expert-recommended DHA. Other components include Vegetable Oil – Palm Olein, Soy, Coconut, High Oleic Sunflower Oils – for a healthy fat source and Corn Syrup Solids as the primary carbohydrate content.
Mortierella Alpina Oil and Schizochytrium Sp. Oil provide The Omega-3 Fat DHA and Omega-6 Fat ARA required for baby’s eye and brain development.
Importantly, it avoids GMOs, making it an appealing option for those who prefer a non-genetically modified diet for their infants.
*Related: Enfamil Gentlease vs Similac Total Comfort
Similac Pro-Total Comfort
Similac Pro-Total Comfort is another leading formula known for being easily digestible.
This offering from Similac stands out due to its inclusion of 2′-FL HMO (2′-fucosyllactose), a prebiotic found in breast milk that strengthens your baby’s developing immune system.
The Formula gets its protein from partially hydrolyzed whey protein which is easier on the baby’s tummy as it has been broken down into smaller pieces.
For carbohydrates, It uses Corn Maltodextrin and sugar, whereas high oleic safflower oil and coconut oil contribute towards healthy fats.
Moreover, Similac Pro-Total Comfort also provides crucial nutrients required for your baby’s proper growth, such as DHA and lutein derived from Schizochytrium sp Oil which aids in brain & eye development coupled with immune support.
It’s also GMO-free.
Nutritional Composition
Enfamil Gentlease and Similac Pro-Total Comfort both use partially hydrolyzed proteins.
Enfamil Gentlease obtains its carbohydrates from corn syrup solids, while Similac Pro-Total Comfort uses corn maltodextrin and sugar.
Both formulas contain a blend of fats and oils, but Enfamil Gentlease includes palm olein, which is controversial.
Similac Pro-Total Comfort has a better fat content by not including palm olein.
Protein Content
Enfamil Gentlease derives its protein content from partially hydrolyzed nonfat milk and whey protein concentrate solids.
Similac Pro-Comfort also uses partially hydrolyzed whey protein.
Both formulas have a very similar approach to protein content and sources.
Partial hydrolyzation means these proteins have been broken down into smaller parts to aid digestion and reduce the risk of potential allergies.
Important: If your baby has CMPA, you should look for an extensively hydrolyzed formula, and not partially.
*Learn more: Hydrolyzed infant formulas
Carbohydrate Content
Enfamil Gentlease collects its primary carbohydrate content from corn syrup solids.
Carbohydrates in Similac Pro-Total Comfort come from corn maltodextrin and sugar.
In theory, corn maltodextrin is a better alternative to lactose than corn syrup solids because it has less sugar, which means that Pro-Comfort would have a better carbohydrate source.
However, Pro-Comfort adds added sugar in addition to maltodextrin. The only reason for doing this is that it adds palatability. This is not recommended as the taste of the formula; the more neutral, the better.
For this reason, there would be a technical tie between the two formulas as far as carbohydrates are concerned.
*Learn more: Corn Syrup in Formula
Fats and Oils
Enfamil Gentlease includes vegetable oil (palm olein, soy, coconut, high oleic sunflower oils), Schizochytrium sp oil (a source of DHA), and Mortierella Alpina oil (which provides ARA).
Pro Total Comfort utilizes a blend of high oleic safflower oil, soy oil, coconut oil for healthy fats supply alongside DHA & ARA yielding Schizochytrium sp oil for baby’s brain & eyes development.
Pro Comfort has a better fat content just because it does not have palm olein like Gentlease does.
Palm olein is a controversial ingredient that, while it has some benefits, we do not think is worth putting in a formula, unless it comes from organic sources.
Learn more: Palm Oil in Formula
Probiotics and Prebiotics
Enfamil Gentlease does not include prebiotics or probiotics.
Similac Pro-Total Comfort contains 2′-FL HMO, a prebiotic found in breast milk.
Prebiotics and Probiotics promote a healthy gut environment, boost the immune system, and support overall infant health.
Enfamil Gentlease does not contain any pre or probiotics
Similac Pro-Total Comfort formula includes 2′-FL HMO, a powerful prebiotic in breast milk. This aids in strengthening the baby’s immune system while nourishing the growth of good gut bacteria, which is vital for digestive health.
Best Places to Buy Enfamil Gentlease and Similac Pro-Total Comfort
Enfamil Gentlease
Buy Enfamil Gentlease at Target
Buy Enfamil Gentlease at Warlmart
Similac Pro-Total Comfort
Buy Similac Pro-Total Comfort at Target
Buy Similac Pro-Total Comfort at Walmart
What are the best alternatives to Enfamil Gentlease and Similac Pro-Total Comfort?
There are other sensitive formulas that we consider better options than Gentlease and Pro-Total Comfort. For one, we would always choose an organic formula. Here are our top recommendations:
1. Hipp HA
Hipp HA formula is another great pick if you’re looking for a hypoallergenic formula. It is suitable for babies who potentially have allergies because of its hydrolyzed protein content that helps prevent triggering allergic reactions. *Read: Hipp Ha vs Enfamil Gentlease
2. Hipp Comfort and Anti-Reflux
Hipp Comfort and Anti-Reflux formulas could be perfect options for those babies struggling with acid reflux or lactose sensitivity problems. They promote comfortable digestion because of their adjusted levels of lactose, making these formulas very gentle on your little one’s tummy. *Read: Hipp Comfort vs Anti-Reflux
3. Goat Milk Formulas
High-quality goat milk formulas can also be excellent alternatives for babies without Cow’s Milk Protein Allergy (CMPA). Goat milk-based formulas are easier to digest and could make a difference if your baby has trouble digesting cow’s milk formula. *Read: Goat vs Cow Milk Formulas
Last Words
We hope this comparison between Enfamil Gentlease and Similac Pro-Comfort helps you make an informed decision.
We recommend you read about the alternatives above until you find a formula you are comfortable with.
If you have further questions, please leave a comment below, and we’ll get back to you in less than 24 hours.
See you around!
We’re Maria and Alberto, a married couple and educators who are nutrition enthusiasts. Even before we had kids, we were already crazy about nutrition.
We’d read scientific articles, watch videos from nutritionists, and spend hours listening to nutrition podcasts.
Today, we continue doing this, but in a different way, as we’ve learned to sift through the noise and trends. Nutrition, like any other field of knowledge, the more you read and learn, the more you develop a comprehensive understanding of reality, and that’s what has happened to us.
Before having our first child, we focused on learning everything we could about child nutrition, using the same techniques we had already employed, backed by our extensive knowledge in nutrition.
Our mission is to help other parents with their children’s nutrition, to help them become the best versions of themselves.
If we are what we eat and drink, which is absolutely true, let’s do it right!
